Understanding, predicting and achieving liver transplant tolerance: from bench to bedside

AW Thomson, J Vionnet… - Nature Reviews …, 2020 - nature.com
In the past 40 years, liver transplantation has evolved from a high-risk procedure to one that
offers high success rates for reversal of liver dysfunction and excellent patient and graft …

[PDF][PDF] Cell migration and chimerism after whole‐organ transplantation: the basis of graft acceptance

TE Starzl, AJ Demetris, M Trucco, N Murase… - …, 1993 - Wiley Online Library
Improvements in the prevention or control of rejection of the kidney and liver have been
largely interchangeable (1, 2) and then applicable, with very little modification, to thoracic …

Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts

S Bhattacharjee, F Hamberger… - The Journal of …, 2024 - Am Soc Clin Investig
Cancer-associated fibroblasts (CAF) may exert tumor-promoting and tumor-suppressive
functions, but the mechanisms underlying these opposing effects remain elusive. Here, we …

A surgical experience with five hundred thirty liver transplants in the rat

N Kamada, RY Calne - Surgery, 1983 - surgjournal.com
A surgical experience with 530 orthotopic liver transplants in rats is reviewed with technical
details. Liver transplantation in the rat can provide important data in a variety of areas …

[PDF][PDF] Murine liver allograft transplantation: tolerance and donor cell chimerism

S Qian, AJ Demetris, N Murase, AS Rao, JJ Fung… - …, 1994 - Wiley Online Library
Nonarterialized orthotopic liver transplantation with no immunosuppression was performed
in 13 mouse‐strain combinations. Two strain combinations with major histocompatibility …

The liver as a site of T-cell apoptosis: graveyard, or killing field?

IN Crispe, T Dao, K Klugewitz… - Immunological …, 2000 - search.ebscohost.com
The liver is a site at which apoptotic CD8+ cells accumulate during the clearance phase of
peripheral immune responses. Normal mouse liver contains an unusual mixture of …

History of clinical transplantation

TE Starzl - World journal of surgery, 2000 - Wiley Online Library
The emergence of transplantation has seen the development of increasingly potent
immunosuppressive agents, progressively better methods of tissue and organ preservation …

Hepatocytes induce functional activation of naive CD8+ T lymphocytes but fail to promote survival

P Bertolino, MC Trescol‐Biémont… - European journal of …, 1998 - Wiley Online Library
Intraperitoneal peptide injection of TCR‐transgenic mide or expression of antigen in
hepatocytes leads to an accumulation in the liver of specific apoptotic CD8+ T cells …

Presence of hematopoietic stem cells in the adult liver

H Taniguchi, T Toyoshima, K Fukao, H Nakauchi - Nature medicine, 1996 - nature.com
Recently, cases have been reported in which a mixed chimeric state of blood cells is
established after liver transplantation. Because the established chimerism may have aided …

Innate immune response and hepatic inflammation

G Szabo, P Mandrekar… - Seminars in liver disease, 2007 - thieme-connect.com
Inflammation is a pathogenic component of various types of acute and chronic liver
diseases, and it contributes to progressive liver damage and fibrosis. Cells of the innate …