OBJECTIVE: Large health care utilization databases are frequently used in variety of
settings to study the use and outcomes of therapeutics. Their size allows the study of …

Drug repurposing is an interesting field in the drug discovery scope because of reducing
time and cost. It is also considered as an appropriate method for finding medications for …

Objective To describe rates and risk factors for prolonged postoperative use of opioids in
patients who had not previously used opioids and undergoing major elective surgery …

Background This study evaluated the risk of long-term analgesic use after low-risk surgery in
older adults not previously prescribed analgesics. Methods We conducted a retrospective …

Background The Randomized Aldactone Evaluation Study (RALES) demonstrated that
spironolactone significantly improves outcomes in patients with severe heart failure. Use of …

Understanding how healthcare dollars are spent and attributing healthcare spending to
individuals is an important activity for accountability and comparative performance …

Background—Current observational studies on warfarin use and the risk for stroke and
bleeding in patients with atrial fibrillation (AF) undergoing dialysis found conflicting results …

Aims The objective of the study was to quantify the association between SGLT2 inhibitors
and genital mycotic infection and between SGLT2 inhibitors and urinary tract infection (UTI) …

Background and Purpose: Spontaneous intracerebral hemorrhage (ICH) is a devastating
form of stroke associated with significant morbidity and mortality. Recent epidemiological …

Context Osteoporosis is associated with significant morbidity and mortality. Oral
bisphosphonates have become a mainstay of treatment, but concerns have emerged that …