Glutathione (GSH) is an important antioxidant implicated in several physiological functions,
including the oxidation− reduction reaction balance and brain antioxidant defense against …

Bipolar disorder is manifested as severe dysregulation of mood with recurrent manic and
major depressive episodes. It is associated with psychiatric and medical comorbidities …

Mood and psychotic syndromes most often emerge during adolescence and young
adulthood, a period characterised by major physical and social change. Consequently, the …

Schizophrenia continues to be an illness with poor outcome. Most mechanistic changes
occur many years before the first episode of schizophrenia; these are not reversible after the …

Bipolar disorder (BD) is a long-recognized severe and common psychiatric disorder, with a
complex and often diverse range of presentations. BD is a heterogenous disorder that has …

Background Prior work suggests that adult bipolar disorder (BD) is associated with
increased oxidative stress and inflammation. This exploratory study examined markers of …

Objective: Oxidative stress and mitochondrial dysfunction are 2 closely integrated processes
implicated in the physiopathology of bipolar disorder. Advanced proton magnetic resonance …

Fronto-limbic connectivity is compromised in mood disorders, as reflected by impairments in
white matter (WM) integrity revealed by diffusion tensor imaging. Although the underlying …

Over 200 in vivo magnetic resonance spectroscopy (MRS) studies of substance use and
related disorders (SUD) were published this past decade. The large majority of this work …

Objectives To evaluate the odds for bipolar disorder (BP) mania and depression-related
hospitalization due to cannabis use disorders (CUD). Methods We conducted a cross …