Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

Prostate cancer (PCa) is one of the most commonly diagnosed malignancies and among the
leading causes of cancer-related death worldwide. It is a highly heterogeneous disease …

The lack of in vitro prostate cancer models that recapitulate the diversity of human prostate
cancer has hampered progress in understanding disease pathogenesis and therapy …

Noncoding RNAs (ncRNAs) are emerging as key molecules in human cancer, with the
potential to serve as novel markers of disease and to reveal uncharacterized aspects of …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

Abstract Context Prostate cancer (PCa) is a clinically heterogeneous disease with marked
variability in patient outcomes. Molecular characterization has revealed striking mutational …

Prostate cancer is a common heterogeneous disease, and most patients diagnosed in the
post prostate-specific antigen (PSA) era present with clinically localized disease, the …

CONTEXT: In 2005, fusions between the androgen-regulated transmembrane protease
serine 2 gene, TMPRSS2, and E twenty-six (ETS) transcription factors were discovered in …

Chromosomal rearrangements that result in high level expression of ETS gene family
members are common events in human prostate cancer. Most frequently, the androgen …

Background: The discovery of ERG/ETV 1 gene rearrangements and PTEN gene loss
warrants investigation in a mechanism-based prognostic classification of prostate cancer …