Radiation-induced fibrosis: mechanisms and implications for therapy

JM Straub, J New, CD Hamilton, C Lominska… - Journal of cancer …, 2015 - Springer
Purpose Radiation-induced fibrosis (RIF) is a long-term side effect of external beam
radiation therapy for the treatment of cancer. It results in a multitude of symptoms that …

[HTML][HTML] Improving radiotherapy in cancer treatment: Promises and challenges

HHW Chen, MT Kuo - Oncotarget, 2017 - ncbi.nlm.nih.gov
Effective radiotherapy for cancer has relied on the promise of maximally eradicating tumor
cells while minimally killing normal cells. Technological advancement has provided state-of …

Radiation-induced heart disease: pathologic abnormalities and putative mechanisms

NK Taunk, BG Haffty, JB Kostis, S Goyal - Frontiers in oncology, 2015 - frontiersin.org
Breast cancer is a common diagnosis in women. Breast radiation has become critical in
managing patients who receive breast conserving surgery, or have certain high-risk features …

Radiation‐induced normal tissue damage: oxidative stress and epigenetic mechanisms

J Wei, B Wang, H Wang, L Meng… - Oxidative medicine …, 2019 - Wiley Online Library
Radiotherapy (RT) is currently one of the leading treatments for various cancers; however, it
may cause damage to healthy tissue, with both short‐term and long‐term side effects …

Radioprotection and radiomitigation: from the bench to clinical practice

E Obrador, R Salvador, JI Villaescusa, JM Soriano… - Biomedicines, 2020 - mdpi.com
The development of protective agents against harmful radiations has been a subject of
investigation for decades. However, effective (ideal) radioprotectors and radiomitigators …

[HTML][HTML] Interactions between TGF-β1, canonical WNT/β-catenin pathway and PPAR γ in radiation-induced fibrosis

A Vallée, Y Lecarpentier, R Guillevin, JN Vallée - Oncotarget, 2017 - ncbi.nlm.nih.gov
Radiation therapy induces DNA damage and inflammation leading to fibrosis. Fibrosis can
occur 4 to 12 months after radiation therapy. This process worsens with time and years …

[HTML][HTML] Novel concepts in radiation-induced cardiovascular disease

JR Cuomo, GK Sharma, PD Conger… - World journal of …, 2016 - ncbi.nlm.nih.gov
Radiation-induced cardiovascular disease (RICVD) is the most common nonmalignant
cause of morbidity and mortality among cancer survivors who have undergone mediastinal …

Deep Learning-Guided Fiberoptic Raman Spectroscopy Enables Real-Time In Vivo Diagnosis and Assessment of Nasopharyngeal Carcinoma and Post-treatment …

C Shu, H Yan, W Zheng, K Lin, A James… - Analytical …, 2021 - ACS Publications
In this work, we develop a deep learning-guided fiberoptic Raman diagnostic platform to
assess its ability of real-time in vivo nasopharyngeal carcinoma (NPC) diagnosis and post …

Reactive oxygen species drive epigenetic changes in radiation‐induced fibrosis

S Shrishrimal, EA Kosmacek… - … medicine and cellular …, 2019 - Wiley Online Library
Radiation‐induced fibrosis (RIF) develops months to years after initial radiation exposure.
RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant …

Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis

Y Wang, S Chen, S Bao, L Yao, Z Wen, L Xu… - Frontiers in …, 2024 - frontiersin.org
This review explores the mechanisms of chronic radiation-induced skin injury fibrosis,
focusing on the transition from acute radiation damage to a chronic fibrotic state. It reviewed …