MHC class I antigen processing and presenting machinery: organization, function, and defects in tumor cells
Conditional gene expression has greatly facilitated the examination of the functions of
particular gene products. Using the Cre/lox P switching expression system, we plan to …
particular gene products. Using the Cre/lox P switching expression system, we plan to …
Antigen processing and immune regulation in the response to tumours
E Reeves, E James - Immunology, 2017 - Wiley Online Library
The MHC class I and II antigen processing and presentation pathways display peptides to
circulating CD 8+ cytotoxic and CD 4+ helper T cells respectively to enable pathogens and …
circulating CD 8+ cytotoxic and CD 4+ helper T cells respectively to enable pathogens and …
Phase I immunotherapeutic trial with long peptides spanning the E6 and E7 sequences of high-risk human papillomavirus 16 in end-stage cervical cancer patients …
GG Kenter, MJP Welters, ARPM Valentijn… - Clinical cancer …, 2008 - AACR
Purpose: To determine the toxicity, safety, and immunogenicity of a human papillomavirus
16 (HPV16) E6 and E7 long peptide vaccine administered to end-stage cervical cancer …
16 (HPV16) E6 and E7 long peptide vaccine administered to end-stage cervical cancer …
Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation
A remarkable characteristic of the human major histocompatibility complex (MHC) is its
extreme genetic diversity, which is maintained by balancing selection. In fact, the MHC …
extreme genetic diversity, which is maintained by balancing selection. In fact, the MHC …
Defining the genetic susceptibility to cervical neoplasia—A genome-wide association study
PJ Leo, MM Madeleine, S Wang, SM Schwartz… - PLoS …, 2017 - journals.plos.org
A small percentage of women with cervical HPV infection progress to cervical neoplasia,
and the risk factors determining progression are incompletely understood. We sought to …
and the risk factors determining progression are incompletely understood. We sought to …
Genetics and genomics of ankylosing spondylitis
Ankylosing spondylitis (AS) is a common, highly heritable arthropathy, the pathogenesis of
which is poorly understood. The mechanism by which the main gene for the disease, HLA …
which is poorly understood. The mechanism by which the main gene for the disease, HLA …
Genetics of ankylosing spondylitis
PC Robinson, MA Brown - Molecular immunology, 2014 - Elsevier
Ankylosing spondylitis (AS) is a chronic inflammatory arthritis that affects the spine and
sacroiliac joints. It causes significant disability and is associated with a number of other …
sacroiliac joints. It causes significant disability and is associated with a number of other …
Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity
E Reeves, CJ Edwards, T Elliott… - The Journal of …, 2013 - journals.aai.org
Abstract Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims peptides for MHC class I
presentation, influencing the degree and specificity of CD8+ T cell responses. Single …
presentation, influencing the degree and specificity of CD8+ T cell responses. Single …
Regulation of ERAP1 and ERAP2 genes and their disfunction in human cancer
The endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 are two
multifunctional enzymes playing an important role in the biological processes requiring …
multifunctional enzymes playing an important role in the biological processes requiring …
Endoplasmic reticulum aminopeptidases: Biology and pathogenic potential
N Haroon, RD Inman - Nature Reviews Rheumatology, 2010 - nature.com
Abstract Endoplasmic reticulum aminopeptidase 1 (ERAP1) and the closely related ERAP2
are involved in the final trimming of peptides within the endoplasmic reticulum for …
are involved in the final trimming of peptides within the endoplasmic reticulum for …