Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …

Microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative
diseases such as Alzheimer's disease. These cells adopt distinct transcriptional subtypes …

Amyloid-β (Aβ) is thought to be neuronally derived in Alzheimer's disease (AD). However,
transcripts of amyloid precursor protein (APP) and amyloidogenic enzymes are equally …

Abstract Oligodendrocytes (OLs), the myelin-generating cells of the central nervous system
(CNS), are active players in shaping neuronal circuitry and function. It has become …

Reduction of amyloid beta (Aβ) has been shown to be effective in treating Alzheimer's
disease (AD), but the underlying assumption that neurons are the main source of pathogenic …

A genetically valid animal model could transform our understanding of schizophrenia (SCZ)
disease mechanisms. Rare heterozygous loss-of-function (LoF) mutations in GRIN2A …

The temporal lobe of the human brain contains the entorhinal cortex (EC). This region of the
brain is a highly interconnected integrative hub for sensory and spatial information; it also …

Altered transcriptional and epigenetic regulation of brain cell types may contribute to
cognitive changes with advanced age. Using single-nucleus multi-omic DNA methylation …

A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and
epilepsy. Late-onset epilepsy and epileptiform activity can precede cognitive deterioration in …