Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Macrophage polarization refers to the process by which macrophages can produce two
distinct functional phenotypes: M1 or M2. The balance between both strongly affects the …

The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health concern,
and novel therapeutic strategies to prevent T2DM are urgently needed worldwide. Aging is …

Significance: Oxidative stress represents the common hallmark of pathological conditions
associated with cardiovascular disease (CVD), including atherosclerosis, heart failure …

Aging is a complex phenomenon and its impact is becoming more relevant due to the rising
life expectancy and because aging itself is the basis for the development of age-related …

In diabetes mellitus, the polyol pathway is highly active and consumes approximately 30%
glucose in the body. This pathway contains 2 reactions catalyzed by aldose reductase (AR) …

Genetic inhibition of autophagy induces degenerative changes in mammalian tissues that
resemble those associated with aging, and normal and pathological aging are often …

Lines of evidence from several studies have shown that increases in life expectancy are now
accompanied by increased disability rate. The expanded lifespan of the aging population …

Accumulation of dysfunctional and damaged cellular proteins and organelles occurs during
aging, resulting in a disruption of cellular homeostasis and progressive degeneration and …

Cardiovascular disease (CVD) due to atherosclerosis is the main cause of death in both the
elderly and patients with metabolic diseases, including diabetes. Aging processes contribute …