Programmable molecular signal transmission architecture and reactant regeneration strategy driven by EXO λ for DNA circuits

X Zhang, X Liu, Y Yao, Y Liu, C Zeng… - ACS Synthetic …, 2023 - ACS Publications
The characteristics of DNA hybridization enable molecular computing through strand
displacement reactions, facilitating the construction of complex DNA circuits, which is an …

NeuralCRNs: A Natural Implementation of Learning in Chemical Reaction Networks

RT Nagipogu, JH Reif - arXiv preprint arXiv:2409.00034, 2024 - arxiv.org
The remarkable ability of single-celled organisms to sense and react to the dynamic
changes in their environment is a testament to the adaptive capabilities of their internal …

A signal transmission strategy driven by gap-regulated exonuclease hydrolysis for hierarchical molecular networks

X Liu, X Zhang, S Cui, S Xu, R Liu, B Wang… - Communications …, 2024 - nature.com
Exonucleases serve as efficient tools for signal processing and play an important role in
biochemical reactions. Here, we identify the mechanism of cooperative exonuclease …

Arbitrary Digital DNA Computing: A Programmable Molecular Perceptron Driven by Lambda Exonuclease for Lighting up Concatenated Circuits

X Zhang, X Liu, X Zhang, S Cui, Y Yao… - … Applied Materials & …, 2024 - ACS Publications
DNA circuits, as a type of biochemical system, have the capability to synchronize the
perception of molecular information with a chemical reaction response and directly process …

Engineering a dual-loop molecular circuit with buffering capability to solve molecular information tasks

X Liu, S Cui, X Zhang, Y Yao, B Zhang, B Wang… - Nanoscale, 2024 - pubs.rsc.org
Molecular circuits, as an effective strategy for implementing artificial biochemical networks,
have been widely constructed to process molecular-level information tasks both in vivo and …

A nicking enzyme-assisted allosteric strategy for self-resetting DNA switching circuits

H Wang, X Zhang, Y Liu, S Zhou - Analyst, 2024 - pubs.rsc.org
The self-regulation of biochemical reaction networks is crucial for maintaining balance,
stability, and adaptability within biological systems. DNA switching circuits, serving as basic …

G-quadruplex-regulated exonuclease cooperative hydrolysis signal transduction strategy for processing molecular temporal information

F Zhou, X Liu, S Xu, S Cui, X Zhang, H Man… - New Journal of …, 2024 - pubs.rsc.org
DNA circuits, as a crucial tool for processing molecular information, achieve precise control
of complex molecular reactions within biological systems, demonstrating significant potential …

Engineering Modular DNA Reaction Networks for Signal Processing

S Cui, X Liu, X Zhang, P Shi, Y Zheng… - … A European Journal, 2024 - Wiley Online Library
Diversified molecular information‐processing methods have significant implications for
nanoscale manipulation and control, monitoring and disease diagnosis of organisms, and …

DNA cascading circuits based on combinatorial strand displacement

Y Zhu, S Tan, X Zheng - Fourth International Conference on …, 2024 - spiedigitallibrary.org
Due to their high programmability and versatility, DNA circuits have been widely used for
molecular information processing at the nanoscale. The biocompatibility of DNA circuits …