Nutrients usually act in a coordinated manner in the body. Intestinal absorption and
subsequent metabolism of a particular nutrient, to a certain extent, is dependent on the …

The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …

Rationale: Cardiac aging is an important contributing factor for heart failure, which affects a
large population but remains poorly understood. Objective: The purpose of this study is to …

Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases
expressed on the cell membrane that play crucial roles in both developmental and adult …

The past 15 years have witnessed tremendous progress in the molecular understanding of
osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the …

The hormonal metabolite of vitamin D, 1α, 25-dihydroxyvitamin D 3 (1, 25D), initiates
biological responses via binding to the vitamin D receptor (VDR). When occupied by 1, 25D …

Magnesium is essential for maintaining normal cellular and organ function. In-adequate
magnesium balance is associated with various disorders, such as skeletal deformities …

Chronic kidney disease (CKD) shares many phenotypic similarities with other chronic
diseases, including heart failure, chronic obstructive pulmonary disease, HIV infection and …

The conformationally flexible secosteroid, 1α, 25 (OH) 2vitamin D3 (1α, 25 (OH) 2D3)
initiates biological responses via binding to the vitamin D receptor (VDR). The VDR contains …