Pathophysiology of motor dysfunction in Parkinson's disease as the rationale for drug treatment and rehabilitation

F Magrinelli, A Picelli, P Tocco, A Federico… - Parkinson's …, 2016 - Wiley Online Library
Cardinal motor features of Parkinson's disease (PD) include bradykinesia, rest tremor, and
rigidity, which appear in the early stages of the disease and largely depend on …

Prevalence of freezing of gait in Parkinson's disease: a systematic review and meta-analysis

WS Zhang, C Gao, YY Tan, SD Chen - Journal of neurology, 2021 - Springer
Background Freezing of gait (FOG) is considered one of the most disturbing and least
understood symptoms in Parkinson's disease (PD). The reported prevalence rates of FOG in …

[HTML][HTML] Model-based and model-free machine learning techniques for diagnostic prediction and classification of clinical outcomes in Parkinson's disease

C Gao, H Sun, T Wang, M Tang, NI Bohnen… - Scientific reports, 2018 - nature.com
In this study, we apply a multidisciplinary approach to investigate falls in PD patients using
clinical, demographic and neuroimaging data from two independent initiatives (University of …

[HTML][HTML] Diffusion tensor imaging in Parkinson's disease: review and meta-analysis

C Atkinson-Clement, S Pinto, A Eusebio, O Coulon - NeuroImage: Clinical, 2017 - Elsevier
Background Neuroimaging studies help us better understand the pathophysiology and
symptoms of Parkinson's disease (PD). In several of these studies, diffusion tensor imaging …

The functional network signature of heterogeneity in freezing of gait

KA Ehgoetz Martens, JM Hall, MJ Georgiades, M Gilat… - Brain, 2018 - academic.oup.com
Freezing of gait is a complex, heterogeneous, and highly variable phenomenon whose
pathophysiology and neural signature remains enigmatic. Evidence suggests that freezing is …

Brain structural and functional connectivity in P arkinson's disease with freezing of gait

E Canu, F Agosta, E Sarasso, MA Volonte… - Human brain …, 2015 - Wiley Online Library
Objective To use a multimodal approach to assess brain structural pathways and resting
state (RS) functional connectivity abnormalities in patients with Parkinson's disease and …

The next step: a common neural mechanism for freezing of gait

SJG Lewis, JM Shine - The Neuroscientist, 2016 - journals.sagepub.com
Freezing of gait is a disabling symptom of Parkinson's disease that causes a paroxysmal
cessation of normal footsteps while walking. Despite a great deal of empirical research, the …

[HTML][HTML] Repetitive transcranial magnetic stimulation improves Parkinson's freezing of gait via normalizing brain connectivity

TM Mi, S Garg, F Ba, AP Liu, PP Liang, LL Gao… - npj Parkinson's …, 2020 - nature.com
Robust, effective treatments for Parkinson's freezing of gait remain elusive. Our previous
study revealed beneficial effects of high-frequency rTMS over the supplementary motor area …

Cognition and freezing of gait in Parkinson's disease: A systematic review and meta-analysis

AS Monaghan, E Gordon, L Graham, E Hughes… - Neuroscience & …, 2023 - Elsevier
Freezing of gait (FOG) is a common and disabling symptom in people with Parkinson's
Disease (PwPD). Although cognition is thought to be worse in PwPD who freeze, a …

Gait and balance in Parkinson's disease subtypes: objective measures and classification considerations

T Herman, A Weiss, M Brozgol, N Giladi… - Journal of …, 2014 - Springer
Parkinson's disease (PD) is often divided into tremor dominant (TD) and postural instability
gait difficulty (PIGD) subtypes. However, objective measures of gait (eg, stride length …