Non-coding RNA
JS Mattick, IV Makunin - Human molecular genetics, 2006 - academic.oup.com
The term non-coding RNA (ncRNA) is commonly employed for RNA that does not encode a
protein, but this does not mean that such RNAs do not contain information nor have function …
protein, but this does not mean that such RNAs do not contain information nor have function …
Environmental epigenomics and disease susceptibility
RL Jirtle, MK Skinner - Nature reviews genetics, 2007 - nature.com
Epidemiological evidence increasingly suggests that environmental exposures early in
development have a role in susceptibility to disease in later life. In addition, some of these …
development have a role in susceptibility to disease in later life. In addition, some of these …
G4access identifies G-quadruplexes and their associations with open chromatin and imprinting control regions
C Esnault, T Magat, A Zine El Aabidine… - Nature …, 2023 - nature.com
Metazoan promoters are enriched in secondary DNA structure-forming motifs, such as G-
quadruplexes (G4s). Here we describe 'G4access', an approach to isolate and sequence …
quadruplexes (G4s). Here we describe 'G4access', an approach to isolate and sequence …
[HTML][HTML] Genomic basis for RNA alterations in cancer
PCAWG Transcriptome Core Group Calabrese Claudia … - Nature, 2020 - nature.com
Transcript alterations often result from somatic changes in cancer genomes. Various forms of
RNA alterations have been described in cancer, including overexpression, altered splicing …
RNA alterations have been described in cancer, including overexpression, altered splicing …
Mouse models of human disease: an evolutionary perspective
RL Perlman - Evolution, medicine, and public health, 2016 - academic.oup.com
The use of mice as model organisms to study human biology is predicated on the genetic
and physiological similarities between the species. Nonetheless, mice and humans have …
and physiological similarities between the species. Nonetheless, mice and humans have …
[HTML][HTML] Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia
Intratumoral heterogeneity plays a critical role in tumor evolution. To define the contribution
of DNA methylation to heterogeneity within tumors, we performed genome-scale bisulfite …
of DNA methylation to heterogeneity within tumors, we performed genome-scale bisulfite …
[HTML][HTML] Establishing chromatin regulatory landscape during mouse preimplantation development
How the chromatin regulatory landscape in the inner cell mass cells is established from
differentially packaged sperm and egg genomes during preimplantation development is …
differentially packaged sperm and egg genomes during preimplantation development is …
[HTML][HTML] Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes
Epidemiological studies suggest that a father's diet can influence offspring health. A
proposed mechanism for paternal transmission of environmental information is via the …
proposed mechanism for paternal transmission of environmental information is via the …
The sheep genome illuminates biology of the rumen and lipid metabolism
Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and
represent a distinct class of animals that have a specialized digestive organ, the rumen, that …
represent a distinct class of animals that have a specialized digestive organ, the rumen, that …
Simultaneous profiling of chromatin accessibility and methylation on human cell lines with nanopore sequencing
Probing epigenetic features on DNA has tremendous potential to advance our
understanding of the phased epigenome. In this study, we use nanopore sequencing to …
understanding of the phased epigenome. In this study, we use nanopore sequencing to …