The term non-coding RNA (ncRNA) is commonly employed for RNA that does not encode a
protein, but this does not mean that such RNAs do not contain information nor have function …

Epidemiological evidence increasingly suggests that environmental exposures early in
development have a role in susceptibility to disease in later life. In addition, some of these …

Metazoan promoters are enriched in secondary DNA structure-forming motifs, such as G-
quadruplexes (G4s). Here we describe 'G4access', an approach to isolate and sequence …

Transcript alterations often result from somatic changes in cancer genomes. Various forms of
RNA alterations have been described in cancer, including overexpression, altered splicing …

The use of mice as model organisms to study human biology is predicated on the genetic
and physiological similarities between the species. Nonetheless, mice and humans have …

Intratumoral heterogeneity plays a critical role in tumor evolution. To define the contribution
of DNA methylation to heterogeneity within tumors, we performed genome-scale bisulfite …

How the chromatin regulatory landscape in the inner cell mass cells is established from
differentially packaged sperm and egg genomes during preimplantation development is …

Epidemiological studies suggest that a father's diet can influence offspring health. A
proposed mechanism for paternal transmission of environmental information is via the …

Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and
represent a distinct class of animals that have a specialized digestive organ, the rumen, that …

Probing epigenetic features on DNA has tremendous potential to advance our
understanding of the phased epigenome. In this study, we use nanopore sequencing to …