Condensins are large protein complexes that play a central role in chromosome
organization and segregation in the three domains of life. They display highly characteristic …

Mitosis and meiosis are remarkable processes during which cells undergo profound
changes in their structure and physiology. These events are orchestrated with a precision …

Condensin is a protein complex associated with mitotic chromosomes that has been
implicated in chromosome condensation. In vertebrates, two types of condensin complexes …

Our understanding of the structure and function of mitotic chromosomes has come a long
way since these iconic objects were first recognized more than 140 years ago, though many …

Structural maintenance of chromosomes (SMC) proteins are chromosomal ATPases, highly
conserved from bacteria to humans, that play fundamental roles in many aspects of higher …

During mitosis, replicated chromosomes segregate such that each daughter cell receives
one copy of the genome. Faithful mechanical transport during mitosis requires that …

Background Restructuring chromatin into morphologically distinct chromosomes is essential
for cell division, but the molecular mechanisms underlying this process are poorly …

Condensins are multi-subunit protein complexes that play a central role in mitotic
chromosome assembly and segregation. The complexes contain 'structural maintenance of …

Current models of mitotic chromosome structure are based largely on the examination of
maximally condensed metaphase chromosomes. Here, we test these models by correlating …

Accurate chromosome alignment at metaphase and subsequent segregation of condensed
chromosomes is a complex process involving elaborate and only partially characterized …