Black men with prostate cancer have historically had worse outcomes than white men with
prostate cancer. The causes of this disparity in outcomes are multi-factorial, but a potential …

Abstract Background An important fraction (>/~ 10%) of men with high‐risk, localized
prostate cancer and metastatic prostate cancer carry germline (heritable) pathogenic and …

Importance Germline gene panel testing is recommended for men with advanced prostate
cancer (PCa) or a family history of cancer. While evidence is limited for some genes …

Background Homologous recombination repair mutation (HRRm) status may guide risk-
stratification and treatment decisions, including polyadenosine diphosphate–ribose …

Germline testing is becoming increasingly relevant in prostate cancer (PCa) screening,
prognosis, and management. A subset of patients with PCa harbor pathogenic/likely …

PURPOSE Guidelines for prostate cancer (PCA) germline testing (GT) have expanded, with
impact on clinical management and hereditary cancer assessment. African American (AA) …

Background Significant racial disparities in prostate cancer incidence and mortality have
been reported between African American Men (AAM), who are at increased risk for prostate …

In this study, we used whole-exome sequencing of a cohort of 45 advanced-stage, treatment-
naïve Nigerian (NG) primary prostate cancer tumors and 11 unmatched nontumor tissues to …

Abstract Background African American men are much more likely than Caucasian men to be
diagnosed with and to die of prostate cancer. Genetic differences likely play a role. The …

Abstract Background Prostate cancer (PCa), one of the most prevalent malignancies
affecting men, significantly contributes to increased mortality rates worldwide. While the …