Gene therapy has gained significant attention over the past two decades as a potential
method for treating genetic disorders such as severe combined immunodeficiency, 1 cystic …

Gene therapy provides great opportunities for treating diseases from genetic disorders,
infections and cancer. To achieve successful gene therapy, development of proper gene …

The potential of gene therapy to benefit human health is tremendous because almost all
human diseases have a genetic component, from untreatable monogenic disorders to …

The purpose of this paper is to review the history of using lectins to target and deliver drugs
to their site of action. The hour of birth of “lectinology” may be defined as the description of …

Gene therapy, ie, the expression in cells of genetic material with therapeutic activity, holds
great promise for the treatment of human diseases. A delivery vehicle (vector), of either viral …

Large pore mesoporous silica nanoparticles (LP-MSNs) functionalized with poly-l-lysine
(PLL) were designed as a new carrier material for gene delivery applications. The …

Routine clinical implementation of human gene therapy awaits safe and efficient gene
delivery methods. Polymeric vectors hold promise due to the availability of diverse …

DNA transport through the cell membrane is an essential requirement for gene therapy,
which utilizes oligonucleotides and plasmid DNA. However, membrane transport of DNA is …

Nucleic acids are not only expected to assume a pivotal position as “drugs” in the treatment
of genetic and acquired diseases, but could also act as molecular cues to control the …

Hydrogel nanoparticles—also referred to as polymeric nanogels or macromolecular micelles—
are emerging as promising drug carriers for therapeutic applications. These nanostructures …