The glomerular filtration barrier: a structural target for novel kidney therapies

IS Daehn, JS Duffield - Nature Reviews Drug Discovery, 2021 - nature.com
Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Preeclampsia 2012

E Eiland, C Nzerue, M Faulkner - Journal of pregnancy, 2012 - Wiley Online Library
Preeclampsia is a common complication of pregnancy associated with high maternal
morbidity and mortality and intrauterine fetal growth restriction. There is extensive evidence …

[PDF][PDF] Flavonoids: A vital resource in healthcare and medicine

S Mondal, ST Rahaman - Pharm. Pharmacol. Int. J, 2020 - researchgate.net
There are many biological resources in nature that are essential in relation to health care.
Due to their flexible health benefits documented in various epidemiological studies, there …

Genetic variants in pre-eclampsia: a meta-analysis

AJ Buurma, RJ Turner, JHM Driessen… - Human reproduction …, 2013 - academic.oup.com
BACKGROUND Pre-eclampsia has a clear familial component, suggesting that the condition
may be partly attributable to genetic susceptibility. The search for susceptibility genes has …

Genes and the preeclampsia syndrome

S Mütze, S Rudnik-Schöneborn, K Zerres, W Rath - 2008 - degruyter.com
Preeclampsia is specific to pregnancy and is still a leading cause of maternal and perinatal
mortality and morbidity, affecting about 3% of women, but the underlying pathogenetic …

Pharmacological Effect of Quercetin in Hypertension and Its Potential Application in Pregnancy‐Induced Hypertension: Review of In Vitro, In Vivo, and Clinical …

M Ożarowski, PŁ Mikołajczak… - Evidence‐Based …, 2018 - Wiley Online Library
Since improving maternal and child health is a public health priority worldwide, the main aim
of treatment of hypertension in pregnant women is to prevent complications during …

eNOS deficiency acts through endothelin to aggravate sFlt-1–induced pre-eclampsia–like phenotype

F Li, JR Hagaman, HS Kim, N Maeda… - Journal of the …, 2012 - journals.lww.com
Excess soluble fms-like tyrosine kinase 1 (sFlt-1) of vascular endothelial growth factor
receptor 1 secreted from the placenta causes pre-eclampsia–like features by antagonizing …

[PDF][PDF] Preeclampsia and the kidney: pathophysiology and clinical implications

V Dines, S Suvakov, A Kattah, J Vermunt… - Comprehensive …, 2023 - researchgate.net
Preeclampsia and other hypertensive disorders of pregnancy are major contributors to
maternal morbidity and mortality worldwide. This group of disorders includes chronic …

Molecular aspects of preeclampsia

M Mohaupt - Molecular aspects of medicine, 2007 - Elsevier
Various hypotheses as to the origin of preeclampsia have been explored over time.
Diseases of pregnancy are difficult to study for several reasons. One limitation is due to the …

The polymorphism for endothelial nitric oxide synthase gene, the level of nitric oxide and the risk for pre-eclampsia: a meta-analysis

B Dai, T Liu, B Zhang, X Zhang, Z Wang - Gene, 2013 - Elsevier
Endothelial NO, which is synthesized by endothelial nitric oxide synthase (eNOS), has been
reported to be related with the occurrence of pre-eclampsia (PE). However, the …