During the 19th century, for the first time, the linkage between inflammation and cancer was
established. Inflammatory microenvironment is an essential component of the tumor …

The importance of Ca2+ signalling in key events of cancer cell function and tumour
progression, such as proliferation, migration, invasion and survival, has recently begun to be …

Unlike Western medicines with single-target, the traditional Chinese medicines (TCM)
always exhibit diverse curative effects against multiple diseases through its “multi …

Increasing evidences reveal that autophagy inhibitor could enhance the effect of
chemotherapy to cancer. However, few autophagy inhibitors are currently approved for …

Oxaliplatin (OXA) resistance remains the major obstacle to the successful chemotherapy of
colorectal cancer (CRC). As a self-protection mechanism, autophagy may contribute to …

Abstract Background/Aims: This study aimed to investigate the anti-inflammatory activity of
Berbamine (BER), a bisbenzylisoquinoline alkaloid extracted from Berberis amurensis (Xiao …

Drug-resistant tuberculosis (TB) poses a major threat to global TB control; consequently,
there is an urgent need to develop novel anti-TB drugs or strategies. Host-directed therapy …

Glioblastoma multiforme (GBM) is the most aggressive form of brain tumor. Relapse is
frequent and rapid due to glioblastoma stem-like cells (GSCs) that induce tumor initiation …

Lung cancer is a serious health problem and leading cause of death worldwide due to its
high incidence and mortality. More than 80% of lung cancers feature a non-small cell …

Ovarian cancer is a common and lethal cancer affecting women globally. Berbamine is a
natural compound from the plant Berberis amurensis, which is used in Chinese traditional …