Heart failure with preserved ejection fraction (HFpEF), a major public health problem that is
rising in prevalence, is associated with high morbidity and mortality and is considered to be …

Natriuretic peptides are a family of structurally related but genetically distinct
hormones/paracrine factors that regulate blood volume, blood pressure, ventricular …

The ability of mammals to resist body fat accumulation is linked to their ability to expand the
number and activity of “brown adipocytes” within white fat depots. Activation of β-adrenergic …

Since the discovery in 1957 that cyclic AMP acts as a second messenger for the hormone
adrenaline, interest in this molecule and its companion, cyclic GMP, has grown. Over a …

Systematic studies on the significance of the secretory-like morphological characteristic of
cardiac atrial muscle cells of mammals led to the finding that these cells produce a …

Although cyclic guanosine monophosphate (GMP)'was first described in biological
samplesmore than two decades ago, its role in some physiological processes has only …

A MAJOR mechanism by which insulin stimulates glucose transport in muscle and fat is the
translocation of glucose transporters from an intracellular membrane pool to the cell …

ATRIAL natriuretic peptide (ANP) is a polypeptide hormone whose effects include the
induction of diuresis, natriuresis and vasorelaxation1. One of the earliest events following …

A ring-deleted analog of atrial natriuretic factor—des [Gln18, Ser19, Gly20, Leu21, Gly22]
ANF4-23-NH2 (C-ANF4-23)—binds with high affinity to approximately 99% of ANF receptors …

In mammalian tissues the C-terminal amide structure has been found to occur only in
neuroactive or hormonally-active peptides1. About half known neuropeptide and peptide …