The current state of peritoneal dialysis

R Mehrotra, O Devuyst, SJ Davies… - Journal of the American …, 2016 - journals.lww.com
Technical innovations in peritoneal dialysis (PD), now used widely for the long-term
treatment of ESRD, have significantly reduced therapy-related complications, allowing …

PDGF in organ fibrosis

BM Klinkhammer, J Floege, P Boor - Molecular Aspects of Medicine, 2018 - Elsevier
Fibrosis is part of a tissue repair response to injury, defined as increased deposition of
extracellular matrix. In some instances, fibrosis is beneficial; however, in the majority of …

ISPD recommendations for the evaluation of peritoneal membrane dysfunction in adults: classification, measurement, interpretation and rationale for intervention

J Morelle, J Stachowska-Pietka… - Peritoneal Dialysis …, 2021 - journals.sagepub.com
Lay summary Peritoneal dialysis (PD) uses the peritoneal membrane for dialysis. The
peritoneal membrane is a thin layer of tissue that lines the abdomen. The lining is used as a …

[HTML][HTML] Preventing peritoneal membrane fibrosis in peritoneal dialysis patients

Q Zhou, MA Bajo, G Del Peso, X Yu, R Selgas - Kidney international, 2016 - Elsevier
Long-term peritoneal dialysis causes morphologic and functional changes in the peritoneal
membrane. Although mesothelial-mesenchymal transition of peritoneal mesothelial cells is a …

Molecular pathways in peritoneal fibrosis

MS Balzer - Cellular signalling, 2020 - Elsevier
Peritoneal dialysis (PD) is a renal replacement therapy for patients with end-stage renal
disease that is equivalent to hemodialysis with respect to adequacy, mortality, and other …

[HTML][HTML] Intraperitoneal microbial contamination drives post-surgical peritoneal adhesions by mesothelial EGFR-signaling

J Zindel, J Mittner, J Bayer, SL April-Monn… - Nature …, 2021 - nature.com
Abdominal surgeries are lifesaving procedures but can be complicated by the formation of
peritoneal adhesions, intra-abdominal scars that cause intestinal obstruction, pain, infertility …

Inhibition of hyperglycolysis in mesothelial cells prevents peritoneal fibrosis

M Si, Q Wang, Y Li, H Lin, D Luo, W Zhao… - Science translational …, 2019 - science.org
Progressive peritoneal fibrosis affects patients receiving peritoneal dialysis (PD) and has no
reliable treatment. The mechanisms that initiate and sustain peritoneal fibrosis remain …

Blocking TGF-β1 protects the peritoneal membrane from dialysate-induced damage

J Loureiro, A Aguilera, R Selgas… - Journal of the …, 2011 - journals.lww.com
During peritoneal dialysis (PD), mesothelial cells undergo mesothelial-to-mesenchymal
transition (MMT), a process associated with peritoneal-membrane dysfunction. Because TGF …

[HTML][HTML] Fibrosis of peritoneal membrane as target of new therapies in peritoneal dialysis

V Masola, M Bonomini, S Borrelli, L Di Liberato… - International journal of …, 2022 - mdpi.com
Peritoneal dialysis (PD) is an efficient renal replacement therapy for patients with end-stage
renal disease. Even if it ensures an outcome equivalent to hemodialysis and a better quality …

Carcinoma‐associated fibroblasts derive from mesothelial cells via mesothelial‐to‐mesenchymal transition in peritoneal metastasis

P Sandoval, JA Jiménez‐Heffernan… - The Journal of …, 2013 - Wiley Online Library
Peritoneal dissemination is a frequent metastatic route for cancers of the ovary and
gastrointestinal tract. Tumour cells metastasize by attaching to and invading through the …