BACKGROUND Mammalian germ cells differentiate into oocytes in females and
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …

Male patients with childhood, adolescent, and young adult cancer are at an increased risk
for infertility if their treatment adversely affects reproductive organ function. Future fertility is a …

BACKGROUND Infertility is an important side effect of treatments used for cancer and other
non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells …

Cryopreservation is a key enabling technology in regenerative medicine that provides stable
and secure extended cell storage for primary tissue isolates and constructs and prepared …

Biodiversity is defined as the presence of a variety of living organisms on the Earth that is
essential for human survival. However, anthropogenic activities are causing the sixth mass …

The testis must create and maintain an immune privileged environment to protect maturing
germ cells from autoimmune destruction. The establishment of this protective environment is …

Continued advancements in therapy in pediatric and adolescent oncology have led to
increasing numbers of patients achieving long-term survival. Consequently, conveying the …

Establishment of spermatogonia throughout the fetal and postnatal period is essential for
production of spermatozoa and male fertility. Here, we establish a protocol for in vitro …

Spermatogonial stem cells (SSCs) are the only adult stem cells capable of passing genes
onto the next generation. SSCs also have the potential to provide important knowledge …

Aim To provide practice guidelines about fertility preservation (FP) in oncology. Methods We
selected 400 articles after a PubMed review of the literature (1987–2019) …