The immune checkpoint molecule CD70 and its receptor CD27 are aberrantly expressed in
many hematological and solid malignancies. Dysregulation of the CD70-CD27 axis within …

Hodgkin lymphoma (HL), a B cell–derived cancer, is one of the most common lymphomas. In
HL, the tumor cells—Hodgkin and Reed-Sternberg (HRS) cells—are usually very rare in the …

Background Despite advances in treatments for Hodgkin's lymphoma, about 20% of patients
still die from progressive disease. Current prognostic models predict the outcome of …

Hodgkin's lymphoma (HL) represents the most common subtype of malignant lymphoma in
young people in the Western world. Most patients can be cured with modern treatment …

Background Specific populations of highly tumorigenic cells are thought to exist in many
human tumors, including pancreatic adenocarcinoma. However, the clinical significance of …

Background Cancer stem cells (CSCs) can proliferate and self-renew extensively due to
their ability to express anti-apoptotic and drug resistant proteins, thus sustaining tumor …

Many, if not all, tumours contain a sub‐population of self‐renewing and expanding stem
cells known as cancer stem cells (CSCs). The symmetric division of CSCs is one mechanism …

It has become clear that cancer is not merely a growth of autonomously proliferating cells,
but that other non‐malignant cell types are a functional part of the disease. Immune cells …

Abstract The Hodgkin and Reed-Sternberg (HRS) tumor cells of classical Hodgkin
lymphoma (HL), as well as the lymphocyte predominant (LP) cells of nodular lymphocyte …

Classical Hodgkin lymphoma is curable in the majority of cases with chemotherapy and/or
radiation. However, 15–20% of patients ultimately relapse and succumb to their disease …