Quantification of amyloid PET for future clinical use: a state-of-the-art review
Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer's
disease (AD) pathogenesis. The overall load and spatial distribution of brain Aβ can be …
disease (AD) pathogenesis. The overall load and spatial distribution of brain Aβ can be …
Development of positron emission tomography β-amyloid plaque imaging agents
For 100 years, β-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) have been
recognized as the neuropathological hallmarks of Alzheimer's disease (AD), and their …
recognized as the neuropathological hallmarks of Alzheimer's disease (AD), and their …
Gut microbiome composition may be an indicator of preclinical Alzheimer's disease
Alzheimer's disease (AD) pathology is thought to progress from normal cognition through
preclinical disease and ultimately to symptomatic AD with cognitive impairment. Recent work …
preclinical disease and ultimately to symptomatic AD with cognitive impairment. Recent work …
Regional Aβ-tau interactions promote onset and acceleration of Alzheimer's disease tau spreading
Amyloid-beta and tau are key molecules in the pathogenesis of Alzheimer's disease, but it
remains unclear how these proteins interact to promote disease. Here, by combining cross …
remains unclear how these proteins interact to promote disease. Here, by combining cross …
Longitudinal associations of blood phosphorylated Tau181 and neurofilament light chain with neurodegeneration in Alzheimer disease
Importance Plasma phosphorylated tau at threonine 181 (p-tau181) has been proposed as
an easily accessible biomarker for the detection of Alzheimer disease (AD) pathology, but its …
an easily accessible biomarker for the detection of Alzheimer disease (AD) pathology, but its …
Association between midlife vascular risk factors and estimated brain amyloid deposition
Importance Midlife vascular risk factors have been associated with late-life dementia.
Whether these risk factors directly contribute to brain amyloid deposition is less well …
Whether these risk factors directly contribute to brain amyloid deposition is less well …
In vivo staging of regional amyloid deposition
Objectives: To estimate a regional progression pattern of amyloid deposition from cross-
sectional amyloid-sensitive PET data and evaluate its potential for in vivo staging of an …
sectional amyloid-sensitive PET data and evaluate its potential for in vivo staging of an …
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
In the past 8 years, both the International Working Group (IWG) and the US National Institute
on Aging–Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's …
on Aging–Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's …
Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer's disease: a PET substudy interim analysis
G Klein, P Delmar, N Voyle, S Rehal… - Alzheimer's research & …, 2019 - Springer
Background We previously investigated low doses (105 or 225 mg) of gantenerumab, a fully
human monoclonal antibody that binds and removes aggregated amyloid-β by Fc receptor …
human monoclonal antibody that binds and removes aggregated amyloid-β by Fc receptor …
Cascading network failure across the Alzheimer's disease spectrum
DT Jones, DS Knopman, JL Gunter, J Graff-Radford… - Brain, 2016 - academic.oup.com
Complex biological systems are organized across various spatiotemporal scales with
particular scientific disciplines dedicated to the study of each scale (eg genetics, molecular …
particular scientific disciplines dedicated to the study of each scale (eg genetics, molecular …