Aliphatic three-and four-membered rings including cyclopropanes, cyclobutanes, oxetanes,
azetidines and bicyclo [1.1. 1] pentanes have been increasingly exploited in medicinal …

Cyclobutanes are increasingly used in medicinal chemistry in the search for relevant
biological properties. Important characteristics of the cyclobutane ring include its unique …

Human endocannabinoid systems modulate multiple physiological processes mainly
through the activation of cannabinoid receptors CB1 and CB2. Their high sequence …

Abstract Structure-based virtual ligand screening is emerging as a key paradigm for early
drug discovery owing to the availability of high-resolution target structures,,–and ultra-large …

Abstract The cannabinoid receptor 1 (CB1) is the principal target of the psychoactive
constituent of marijuana, the partial agonist Δ9-tetrahydrocannabinol (Δ9-THC). Here we …

Trans-Δ 9-tetrahydrocannabinol (Δ 9-THC) is the main compound responsible for the
intoxicant activity of Cannabis sativa L. The length of the side alkyl chain influences the …

We report studies pertaining to two isomeric hexahydrocannabinols (HHCs),(9R)-HHC and
(9S)-HHC, which are derivatives of the psychoactive cannabinoids Δ9-and Δ8-THC. HHCs …

The butyl homologues of Δ9-tetrahydrocannabinol, Δ9-tetrahydrocannabutol (Δ9-THCB),
and cannabidiol, cannabidibutol (CBDB), were isolated from a medicinal Cannabis sativa …

Natural and non-natural hexahydrocannabinols (HHC) were first described in 1940 by Adam
and in late 2021 arose on the drug market in the United States and in some European …

Along with cognitive decline, 90% of patients with dementia experience behavioral and
psychological symptoms of dementia, such as psychosis, aggression, agitation, and …