[HTML][HTML] Severe respiratory viral infections: T-cell functions diverging from immunity to inflammation

J Yunis, KR Short, D Yu - Trends in Microbiology, 2023 - cell.com
Respiratory viral infections such as severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) and influenza A virus (IAV) trigger distinct clinical outcomes defined by immunity …

Atypical and non-classical CD45RBlo memory B cells are the majority of circulating SARS-CoV-2 specific B cells following mRNA vaccination or COVID-19

DG Priest, T Ebihara, J Tulyeu, JN Søndergaard… - Nature …, 2024 - nature.com
Resting memory B cells can be divided into classical or atypical groups, but the
heterogenous marker expression on activated memory B cells makes similar classification …

Preschool-age children maintain a distinct memory CD4+ T cell and memory B cell response after SARS-CoV-2 infection

B Manfroi, BT Cuc, A Sokal, A Vandenberghe… - Science Translational …, 2024 - science.org
The development of the human immune system lasts for several years after birth. The impact
of this maturation phase on the quality of adaptive immunity and the acquisition of …

Sarcoidosis-related autoimmune inflammation in COVID-19 convalescent patients

A Rubinstein, I Kudryavtsev, A Malkova… - Frontiers in …, 2023 - frontiersin.org
Currently, there are a large number of reports about the development of autoimmune
conditions after COVID-19. Also, there have been cases of sarcoid-like granulomas in …

Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection

G Yang, J Cao, J Qin, X Mei, S Deng, Y Xia… - … and Targeted Therapy, 2024 - nature.com
The immunoprotective components control COVID-19 disease severity, as well as long-term
adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial …

Role of circulating T follicular helper subsets following Ty21a immunization and oral challenge with wild type S. Typhi in humans

JS Booth, RR Rapaka, MA McArthur… - Frontiers in …, 2024 - frontiersin.org
Despite decades of intense research, our understanding of the correlates of protection
against Salmonella Typhi (S. Typhi) infection and disease remains incomplete. T follicular …

Coordinated expansion of memory T follicular helper and B cells mediates spontaneous clearance of HCV reinfection

M Eisa, E Gomez-Escobar, N Bédard… - Frontiers in …, 2024 - frontiersin.org
Introduction Follicular helper T cells are essential for helping in the maturation of B cells and
the production of neutralizing antibodies (NAbs) during primary viral infections. However …

ATP-P2X7R pathway activation limits the Tfh cell compartment during pediatric RSV infection

C Russo, S Raiden, S Algieri, MJ Bruera… - Frontiers in …, 2024 - frontiersin.org
Background Follicular helper T cells (Tfh) are pivotal in B cell responses. Activation of the
purinergic receptor P2X7 on Tfh cells regulates their activity. We investigated the ATP …

Age-dependent decrease of circulating T follicular helper cells correlates with disease severity in elderly patients with COVID-19

Y Wang, Q Wang, F He, N Qiao, X Li, L Wei, L Sun… - Clinical …, 2024 - Elsevier
Overwhelming evidence has shown that aging is a significant risk factor for COVID-19-
related hospitalizations, death and other adverse health outcomes. Particular T cell subsets …

Regulatory T and CXCR3+ Circulating Tfh Cells Concordantly Shape the Neutralizing Antibody Responses in Individuals Who Have Recovered from Mild COVID-19

X Zheng, R Lu, D Pan, L Peng, R He… - The Journal of …, 2024 - academic.oup.com
Regulatory T (Treg) cells are involved in the antiviral immune response in patients with
coronavirus disease 2019 (COVID-19); however, whether Treg cells are involved in the …