The twenty-first century has already recorded more than ten major epidemic or pandemic
virus emergence events, including the ongoing and devastating coronavirus disease 2019 …

Lassa virus (LASV) is endemic in the rodent populations of Sierra Leone, Nigeria and other
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …

Chirality plays an important role in the development of many pharmaceuticals, being a
general property of 'handedness'; nevertheless, a large number of pharmaceuticals are still …

Lassa fever is a severe viral hemorrhagic fever caused by a zoonotic virus that repeatedly
spills over to humans from its rodent reservoirs. It is currently not known how climate and …

Lassa virus (LASV) infection is expanding outside its traditionally endemic areas in West
Africa, posing a pandemic biothreat. LASV-neutralizing antibodies, moreover, have proven …

Ribavirin is currently the standard of care for treating Lassa fever. However, the human
clinical trial data supporting its use suffer from several serious flaws that render the results …

Ribavirin has been used widely to treat Lassa fever in West Africa since the 1980s.
However, few studies have systematically appraised the evidence for its use. We conducted …

Ribavirin is the only available Lassa fever treatment. The rationale for using ribavirin is
based on one clinical study conducted in the early 1980s. However, reanalysis of previous …

Background Lassa fever is a viral haemorrhagic fever endemic in parts of west Africa. New
treatments are needed to decrease mortality, but pretrial reference data on the disease …

Background Research is urgently needed to reduce the morbidity and mortality of Lassa
fever (LF), including clinical trials to test new therapies and to verify the efficacy and safety of …