Neuronal migration is a fundamental process that governs embryonic brain development. As
such, mutations that affect essential neuronal migration processes lead to severe brain …

Background: Malformations of cortical development (MCD) are increasingly recognized as
an important cause of epilepsy and developmental delay. MCD encompass a wide spectrum …

The molecular mechanisms controlling the differentiation of neural progenitors into distinct
subtypes of neurons during neocortical development are unknown. Here, we report that Fezl …

Cortical intermediate progenitors (IPs) comprise a secondary neuronal progenitor pool that
arises from radial glia (RG). IPs are essential for generating the correct number of cortical …

Periventricular heterotopia (PH) is a disorder characterized by neuronal nodules, ectopically
positioned along the lateral ventricles of the cerebral cortex. Mutations in either of two …

Developmental dyslexia is a common specific childhood learning disorder with a strong
heritable component. Previous studies using different genetic approaches have identified …

Epilepsy and mental retardation, originally of unknown cause, are now known to result from
many defects including cortical malformations, neuronal circuitry disorders and perturbations …

During embryonic development, excitatory projection neurons migrate in the cerebral cortex
giving rise to organised layers. Periventricular heterotopia (PH) is a group of aetiologically …

The actin cytoskeleton regulates many important cellular processes in the brain, including
cell division and proliferation, migration, and cytokinesis and differentiation. These …

Filamin A (FLNa) is a cross-linker of actin filaments and serves as a scaffold protein mostly
involved in the regulation of actin polymerization. It is distributed ubiquitously, and null …