Background The glutamatergic modulator ketamine has created a blueprint for studying
novel pharmaceuticals in the field. Recent studies suggest that “classic” serotonergic …

Methods: This review aims to provide an interdisciplinary overview of recent evidence-based
and clinical knowledge. Results: The scientific evidence for best practice is weak and …

Consciousness is a multidimensional phenomenon, but key dimensions such as awareness
and wakefulness have been described conceptually rather than neurobiologically. We …

Ketamine produces antidepressant effects in patients with treatment-resistant depression,
but its usefulness is limited by its psychotropic side effects. Ketamine is thought to act via …

The neurobiology of the psychedelic experience is not fully understood. Identifying common
brain network changes induced by both classical (ie, acting at the 5-HT 2 receptor) and non …

The ongoing stream of human consciousness relies on two distinct cortical systems, the
default mode network and the dorsal attention network, which alternate their activity in an …

With a growing body of research highlighting the therapeutic potential of experiential
phenomenology which diminishes egoic identity and increases one's sense of …

In this paper, we present the development of the Altered States Database (ASDB), an open-
science project based on a systematic literature review. The ASDB contains psychometric …

Ketamine is an N-methyl-d-aspartate antagonist which is increasingly being researched and
used as a treatment for depression. In low doses, it can cause a transitory modification in …

General anesthesia reversibly alters consciousness, without shutting down the brain
globally. Depending on the anesthetic agent and dose, it may produce different …