▪ Abstract The synthesis and excretion of bile acids comprise the major pathway of
cholesterol catabolism in mammals. Synthesis provides a direct means of converting …

▪ Abstract β-Oxidation occurs in both mitochondria and peroxisomes. Mitochondria catalyze
the β-oxidation of the bulk of short-, medium-, and long-chain fatty acids derived from diet …

Peroxisomal fatty acid degradation in the yeast Saccharomyces cerevisiae requires an array
of β-oxidation enzyme activities as well as a set of auxiliary activities to provide the β …

The biological activity of steroid hormones is regulated at the pre-receptor level by several
enzymes including 17 beta-hydroxysteroid dehydrogenases (17 beta-HSD). The latter are …

Peroxisomal disorders are a group of inherited diseases in man in which either peroxisome
biogenesis or one or more peroxisomal functions are impaired. The peroxisomal disorders …

Peroxisomes are subcellular organelles with an indispensable role in cellular metabolism.
The importance of peroxisomes for humans is stressed by the existence of a group of …

17beta-Hydroxysteroid dehydrogenases (17beta-HSDs) are important enzymes in steroid
metabolism. Long known members of the protein family seemed to be well characterised …

L-bifunctional enzyme (Ehhadh) is part of the classical peroxisomal fatty acid β-oxidation
pathway. This pathway is highly inducible via peroxisome proliferator-activated receptor α …

ABSTRACT A number of enzymes possessing 17βhydroxysteroid dehydrogenase/17-
ketosteroid reductase (17HSD/KSR) activities have been described and cloned, but their …

According to current views, peroxisomal β-oxidation is organized as two parallel pathways:
the classical pathway that is responsible for the degradation of straight chain fatty acids and …