Introduction: Bacterial flagellin, as a pathogen-associated molecular pattern (PAMP), can
activate both innate and adaptive immunity. Its unique structural characteristics endow an …

Vaccine approaches to infectious diseases are widely applied and appreciated. Amongst
them, vectors based on recombinant viruses have shown great promise and play an …

Recognition of specific pathogen associated molecular patterns (PAMPs) is mediated
primarily by members of the Toll-like receptor (TLR) family. Stimulation through these …

Pre-existing immunity to human adenovirus serotype 5 (Ad5) is common in the general
population. Bypassing pre-existing immunity could maximize Ad5 vaccine efficacy …

ABSTRACT E1 deletion adenoviral vectors of the human serotype 5 (AdHu5) and the
chimpanzee serotype 68 (AdC68) expressing the rabies virus glycoprotein (rab. gp) were …

Pre-existent humoral antibody to adenovirus potentially confounds human clinical trials
involving intravascular administration of adenovirus. Using the LNCaP prostate cancer …

To date cancer vaccines have yet to show efficacy in a phase III trial. However, the clinical
benefit seen with monoclonal antibody mediated therapies (eg, Herceptin) has provided …

Vaccines are the most effective and inexpensive prophylactic tool in veterinary medicine.
Ideally, vaccines should induce a lifelong protective immunity against the target pathogen …

Dendritic cells (DCs) are powerful antigen-presenting cells that process antigens and
present peptide epitopes in the context of the major histocompatibility complex molecules to …

We created a hybrid adeno-associated virus (AAV) from two related rhesus macaque
isolates, called AAVrh32. 33, and evaluated it as a vaccine carrier for human …