Citrate is an important substrate in cellular energy metabolism. It is produced in the
mitochondria and used in the Krebs cycle or released into cytoplasm through a specific …

Simple Summary Metabolic rewiring is now considered a hallmark of cancer. Pancreatic
ductal adenocarcinoma (PDAC) extensively rewires its metabolism especially for the …

Elevated serum cholesterol, triglycerides and LDL levels are often associated with an
increased incidence of atherosclerosis and coronary artery disease. The most effective …

The accumulation of toxic hydrophobic bile acids in hepatocytes, observed during chronic
cholestasis, induces substantial modification in the redox state and in mitochondrial …

The role of the obesity cytokine leptin in breast cancer progression has raised interest in
interfering with leptin's actions as a valuable therapeutic strategy. Leptin interacts with its …

Uncoupling proteins (UCPs) form a distinct subfamily of the mitochondrial carrier family
(MCF) SLC25. Four UCPs, Dm UCP4A-C and Dm UCP5, have been identified in Drosophila …

Mitochondrial carriers are a family of structurally related proteins responsible for the
exchange of metabolites, cofactors and nucleotides between the cytoplasm and …

Dyslipidemia is a lipid metabolism disorder associated with the loss of the physiological
homeostasis that ensures safe levels of lipids in the organism. This metabolic disorder can …

The pathogenesis of the adrenocortical cancer (ACC) involves integration of molecular
signals and the interplay of different downstream pathways (ie IGFII/IGF1R, β-catenin, Wnt …

The transport of solutes across the inner mitochondrial membrane is catalyzed by a family of
nuclear-encoded membrane-embedded proteins called mitochondrial carriers (MCs). The …