Liver fibrosis accompanies the progression of chronic liver diseases independent of
etiologies, such as hepatitis viral infection, alcohol consumption, and metabolic-associated …

Advanced liver disease presents a significant worldwide health and economic burden and
accounts for 3.5% of global mortality. When liver disease progresses to organ failure the …

Background Results of small-scale studies have suggested that stem-cell therapy is safe
and effective in patients with liver cirrhosis, but no adequately powered randomised …

The fibrotic process could be easily defined as a pathological excess of extracellular matrix
deposition, leading to disruption of tissue architecture and eventually loss of function; …

Neutrophils, the largest innate immune cell population in humans, are the primary
proinflammatory sentinel in the ischemia-reperfusion injury (IRI) mechanism in orthotopic …

Non-alcoholic fatty liver disease (NAFLD), as one of the main causes of chronic liver disease
worldwide, encompasses a spectrum of liver conditions that are not caused by other …

Control of homeostasis and rapid response to tissue damage in the liver is orchestrated by
crosstalk between resident and infiltrating inflammatory cells. A crucial role for myeloid cells …

Tissue fibrosis, including pulmonary fibrosis, hepatic fibrosis, and cardiac fibrosis, is an
important stage in the development of many diseases. It can lead to structural damage and …

Platelets are tightly connected with the liver, as both their production and their clearance are
mediated by the liver. Platelets, in return, participate in a variety of liver diseases, ranging …

Promising preclinical data suggested that bone marrow–derived mesenchymal stem cells
(BM-MSC) can reduce hepatic fibrosis and stimulate liver regeneration. Preclinical studies …