The gastrointestinal tract is the major source of the related hormones ghrelin and motilin,
which act on structurally similar G protein-coupled receptors. Nevertheless, selective …

Desacyl-ghrelin is a form of ghrelin which lacks acyl-modification of the third serine residue
of ghrelin. Originally, desacyl-ghrelin was considered to be just an inactive form of ghrelin …

Context and objective Prader-Willi syndrome (PWS) is characterized by early-onset
hyperphagia and increased circulating levels of the orexigenic Acylated Ghrelin (AG) …

Ghrelin is a stomach‐derived octanoylated peptide hormone that plays a variety of well‐
established biological roles acting via its specific receptor known as growth hormone …

Blood-borne factors regulate adult hippocampal neurogenesis and cognition in mammals.
We report that elevating circulating unacylated-ghrelin (UAG), using both pharmacological …

Although the brain is composed of numerous cell types, neurons have received the vast
majority of attention in the attempt to understand how this organ functions. Neurons are …

Ghrelin functions primarily as a short-term metabolic switch at the onset of fasting, gearing
the fuel economy away from glucose uptake, conserving glucose for vital functions …

The burden of disability, premature death, escalating health care costs and lost economic
productivity due to obesity and its associated complications including hypertension, stroke …

Irisin is a thermogenic peptide that enables the development of brown adipose tissue from
white adipose tissue by activating the UCP1. This study has been designed to determine the …

The stomach hormone, ghrelin, which is released during food restriction, provides a link
between circulating energy state and adaptive brain function. The maintenance of such …