Structural biology of SARS-CoV-2: open the door for novel therapies

W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

SARS-CoV-2-specific immune response and the pathogenesis of COVID-19

E Gusev, A Sarapultsev, L Solomatina… - International journal of …, 2022 - mdpi.com
The review aims to consolidate research findings on the molecular mechanisms and
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …

Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex

J Chen, B Malone, E Llewellyn, M Grasso… - Cell, 2020 - cell.com
SARS-CoV-2 is the causative agent of the 2019–2020 pandemic. The SARS-CoV-2 genome
is replicated and transcribed by the RNA-dependent RNA polymerase holoenzyme …

A structural view of SARS-CoV-2 RNA replication machinery: RNA synthesis, proofreading and final capping

M Romano, A Ruggiero, F Squeglia, G Maga, R Berisio - Cells, 2020 - mdpi.com
The current coronavirus disease-2019 (COVID-19) pandemic is due to the novel coronavirus
SARS-CoV-2. The scientific community has mounted a strong response by accelerating …

The molecular virology of coronaviruses

E Hartenian, D Nandakumar, A Lari, M Ly… - Journal of Biological …, 2020 - ASBMB
Few human pathogens have been the focus of as much concentrated worldwide attention as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …

[HTML][HTML] Coronavirus RNA proofreading: molecular basis and therapeutic targeting

F Robson, KS Khan, TK Le, C Paris, S Demirbag… - Molecular cell, 2020 - cell.com
Summary The coronavirus disease 2019 (COVID-19) that is wreaking havoc on worldwide
public health and economies has heightened awareness about the lack of effective antiviral …

Overview of SARS-CoV-2 genome-encoded proteins

C Bai, Q Zhong, GF Gao - Science China Life Sciences, 2022 - Springer
Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) has spread rapidly
throughout the world. SARS-CoV-2 is an enveloped, plus-stranded RNA virus with a single …

Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design

B Malone, N Urakova, EJ Snijder… - … Reviews Molecular Cell …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed millions of
people and continues to cause massive global upheaval. Coronaviruses are positive-strand …

Architecture of a SARS-CoV-2 mini replication and transcription complex

L Yan, Y Zhang, J Ge, L Zheng, Y Gao, T Wang… - Nature …, 2020 - nature.com
Non-structural proteins (nsp) constitute the SARS-CoV-2 replication and transcription
complex (RTC) to play a pivotal role in the virus life cycle. Here we determine the atomic …

Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase

JA Newman, A Douangamath, S Yadzani… - Nature …, 2021 - nature.com
There is currently a lack of effective drugs to treat people infected with SARS-CoV-2, the
cause of the global COVID-19 pandemic. The SARS-CoV-2 Non-structural protein 13 …