Targeting metalloenzymes for therapeutic intervention
AY Chen, RN Adamek, BL Dick, CV Credille… - Chemical …, 2018 - ACS Publications
Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …
Recent developments in the synthesis of HIV-1 integrase strand transfer inhibitors incorporating pyridine moiety
AM Starosotnikov, MA Bastrakov - International Journal of Molecular …, 2023 - mdpi.com
Human immunodeficiency virus (HIV) causes one of the most dangerous diseases—
acquired immunodeficiency syndrome (AIDS). An estimated about 40 million people are …
acquired immunodeficiency syndrome (AIDS). An estimated about 40 million people are …
The influence of bioisosteres in drug design: tactical applications to address developability problems
NA Meanwell - Tactics in Contemporary Drug Design, 2015 - Springer
The application of bioisosteres in drug discovery is a well-established design concept that
has demonstrated utility as an approach to solving a range of problems that affect candidate …
has demonstrated utility as an approach to solving a range of problems that affect candidate …
Design, synthesis, and docking studies of new 2-benzoxazolinone derivatives as anti-HIV-1 agents
M Safakish, Z Hajimahdi, R Zabihollahi… - Medicinal Chemistry …, 2017 - Springer
A new class of 2-benzoxazolinone derivatives was designed and synthesized for its anti-
human immunodeficiency virus-1 activity. The benzoxazolinone scaffold could be replaced …
human immunodeficiency virus-1 activity. The benzoxazolinone scaffold could be replaced …
Development of elvitegravir resistance and linkage of integrase inhibitor mutations with protease and reverse transcriptase resistance mutations
Failure of antiretroviral regimens containing elvitegravir (EVG) and raltegravir (RAL) can
result in the appearance of integrase inhibitor (INI) drug-resistance mutations (DRMs). While …
result in the appearance of integrase inhibitor (INI) drug-resistance mutations (DRMs). While …
Evaluation of novel N′-(3-hydroxybenzoyl)-2-oxo-2 H-chromene-3-carbohydrazide derivatives as potential HIV-1 integrase inhibitors
OJ Jesumoroti, D Mnkandhla, M Isaacs, HC Hoppe… - …, 2019 - pubs.rsc.org
In an attempt to identify potential new agents that are active against HIV-1 IN, a series of
novel coumarin-3-carbohydrazide derivatives were designed and synthesised. The toxicity …
novel coumarin-3-carbohydrazide derivatives were designed and synthesised. The toxicity …
Molecular docking study of lamellarin analogues and identification of potential inhibitors of HIV-1 integrase strand transfer complex by virtual screening
C Eurtivong, K Choowongkomon, P Ploypradith… - Heliyon, 2019 - cell.com
Molecular docking has been applied to elucidate the binding of lamellarin analogues with
HIV-1 integrase strand transfer complex (PDB ID: 5U1C). The results suggest hydrogen …
HIV-1 integrase strand transfer complex (PDB ID: 5U1C). The results suggest hydrogen …
Quinolines from the cyclocondensation of isatoic anhydride with ethyl acetoacetate: Preparation of ethyl 4-hydroxy-2-methylquinoline-3-carboxylate and derivatives
NG Jentsch, JD Hume, EB Crull… - Beilstein journal of …, 2018 - beilstein-journals.org
A convenient two-step synthesis of ethyl 4-hydroxy-2-methylquinoline-3-carboxylate
derivatives has been developed starting from commercially available 2-aminobenzoic acids …
derivatives has been developed starting from commercially available 2-aminobenzoic acids …
In silico screening for identification of novel HIV-1 integrase inhibitors using QSAR and docking methodologies
P Gupta, P Garg, N Roy - Medicinal Chemistry Research, 2013 - Springer
Human immunodeficiency virus-1 integrase (HIV-1 IN) is an important target for HIV-1
infection. Here, shape based screening workflow was designed to discover novel inhibitors …
infection. Here, shape based screening workflow was designed to discover novel inhibitors …
Repurposing FDA-approved drugs as HIV-1 integrase inhibitors: an in silico investigation
Abstract The Human Immunodeficiency Virus (HIV) infection is a global pandemic that has
claimed 33 million lives to-date. One of the most efficacious treatments for naïve or …
claimed 33 million lives to-date. One of the most efficacious treatments for naïve or …