[HTML][HTML] Dengue virus infection–a review of pathogenesis, vaccines, diagnosis and therapy

BH Kok, HT Lim, CP Lim, NS Lai, CY Leow, CH Leow - Virus research, 2023 - Elsevier
The transmission of dengue virus (DENV) from an infected Aedes mosquito to a human,
causes illness ranging from mild dengue fever to fatal dengue shock syndrome. The similar …

The complexity of a dengue vaccine: a review of the human antibody response

J Flipse, JM Smit - PLoS neglected tropical diseases, 2015 - journals.plos.org
Dengue is the most prevalent mosquito-borne viral disease worldwide. Yet, there are no
vaccines or specific antivirals available to prevent or treat the disease. Several dengue …

[HTML][HTML] Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients' B cells

Y Cao, B Su, X Guo, W Sun, Y Deng, L Bao, Q Zhu… - Cell, 2020 - cell.com
The COVID-19 pandemic urgently needs therapeutic and prophylactic interventions. Here,
we report the rapid identification of SARS-CoV-2-neutralizing antibodies by high-throughput …

Dengue virus neutralizing antibody: a review of targets, cross-reactivity, and antibody-dependent enhancement

A Sarker, N Dhama, RD Gupta - Frontiers in immunology, 2023 - frontiersin.org
Dengue is the most common viral infection spread by mosquitoes, prevalent in tropical
countries. The acute dengue virus (DENV) infection is a benign and primarily febrile illness …

Potential protective effect of dengue NS1 human monoclonal antibodies against dengue and zika virus infections

R Sootichote, W Puangmanee, S Benjathummarak… - Biomedicines, 2023 - mdpi.com
Due to the lack of an effective therapeutic treatment to flavivirus, dengue virus (DENV)
nonstructural protein 1 (NS1) has been considered to develop a vaccine owing to its lack of …

Human monoclonal antibodies broadly neutralizing against influenza B virus

M Yasugi, R Kubota-Koketsu, A Yamashita… - PLoS …, 2013 - journals.plos.org
Influenza virus has the ability to evade host immune surveillance through rapid viral genetic
drift and reassortment; therefore, it remains a continuous public health threat. The …

Reassessing therapeutic antibodies for neglected and tropical diseases

R Hooft van Huijsduijnen, S Kojima… - PLOS Neglected …, 2020 - journals.plos.org
In the past two decades there has been a significant expansion in the number of new
therapeutic monoclonal antibodies (mAbs) that are approved by regulators. The discovery of …

Acute systemic infection with dengue virus leads to vascular leakage and death through tumor necrosis factor-α and Tie2/angiopoietin signaling in mice lacking type I …

S Phanthanawiboon, K Limkittikul, Y Sakai… - PloS one, 2016 - journals.plos.org
Severe dengue is caused by host responses to viral infection, but the pathogenesis remains
unknown. This is, in part, due to the lack of suitable animal models. Here, we report a non …

An affinity-matured human monoclonal antibody targeting fusion loop epitope of dengue virus with in vivo therapeutic potency

T Kotaki, T Kurosu, A Grinyo-Escuer, E Davidson… - Scientific Reports, 2021 - nature.com
Dengue virus (DENV), from the genus flavivirus of the family flaviviridae, causes serious
health problems globally. Human monoclonal antibodies (HuMAb) can be used to elucidate …

Human neutralizing antibodies for SARS-CoV-2 prevention and immunotherapy

D Zhou, R Zhou, Z Chen - Immunotherapy Advances, 2022 - academic.oup.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of
coronavirus disease 2019 (COVID-19). SARS-CoV-2 has been spreading worldwide since …