Fragile X syndrome (FXS) results from a genetic mutation in a single gene yet produces a
phenotypically complex disorder with a range of neurological and psychiatric problems …

Fragile X syndrome (FXS), the most-frequently inherited form of intellectual disability and the
most-prevalent single-gene cause of autism, results from a lack of fragile X mental …

Do young and old protein molecules have the same probability to be degraded? We
addressed this question using metabolic pulse-chase labeling and quantitative mass …

Consistent with recent reports indicating that neurons differentiated in vitro from human-
induced pluripotent stem cells (hiPSCs) are immature relative to those in the human brain …

The lateral habenula (LHb) has recently emerged as a key brain region in the
pathophysiology of depression. However, the molecular mechanism by which LHb becomes …

Loss of FMRP causes fragile X syndrome (FXS), but the physiological functions of FMRP
remain highly debatable. Here we show that FMRP regulates neurotransmitter release in …

Abstract According to DSM-IV TR and ICD-10, a diagnosis of autism or Asperger Syndrome
precludes a diagnosis of attention-deficit/hyperactivity disorder (ADHD). However, despite …

The CYFIP1/SRA1 gene is located in a chromosomal region linked to various neurological
disorders, including intellectual disability, autism, and schizophrenia. CYFIP1 plays a dual …

Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and the
leading monogenic cause of autism. The condition stems from loss of fragile X mental …

The systematic and quantitative molecular analysis of mutant organisms that has been
pioneered by studies on mutant metabolomes and transcriptomes holds great promise for …