The ability of one enzyme to catalyse multiple, mechanistically distinct transformations likely
played a crucial role in organisms' abilities to adapt to changing external stimuli in the past …

Recent developments in synthetic biology, combined with continued progress in systems
biology and metabolic engineering, have enabled the engineering of microorganisms to …

P450BM3 (CYP102A1), a fatty acid hydroxylase from Bacillus megaterium, has been
extensively studied over a period of almost forty years. The enzyme has been redesigned to …

Metabolic engineering has the potential to produce from simple, readily available,
inexpensive starting materials a large number of chemicals that are currently derived from …

Cytochrome P450 monooxygenases (P450s) are versatile biocatalysts that catalyze the
regio-and stereospecic oxidation of non-activated hydrocarbons under mild conditions …

Plants of Artemisia annua produce artemisinin, a sesquiterpene lactone widely used in
malaria treatment. Amorpha-4, 11-diene synthase (ADS), a sesquiterpene synthase, and …

The development of catalytic systems for the controlled oxidation of C–H bonds remains a
highly sought-after goal in chemistry owing to the great utility of such transformation toward …

This critical review presents an introduction to biocatalysis for synthetic chemists. Advances
in biocatalysis of the past 5 years illustrate the breadth of applications for these powerful and …

Biocatalysis is an enabling technology adding to organic oxidation chemistry. Especially the
high selectivity of enzymatic oxidation coevally operating under mild conditions and not …

The Chinese medicinal plant Artemisia annua L.(Qinghao) is the only known source of the
sesquiterpene artemisinin (Qinghaosu), which is used in the treatment of malaria …