HIV-associated neurocognitive disorder—pathogenesis and prospects for treatment

D Saylor, AM Dickens, N Sacktor, N Haughey… - Nature Reviews …, 2016 - nature.com
In the past two decades, several advancements have improved the care of HIV-infected
individuals. Most importantly, the development and deployment of combination antiretroviral …

Axonal damage: a key predictor of outcome in human CNS diseases

IM Medana, MM Esiri - Brain, 2003 - academic.oup.com
Axonal damage has recently been recognized to be a key predictor of outcome in a number
of diverse human CNS diseases, including head and spinal cord trauma, metabolic …

Brain deposition of beta-amyloid is a common pathologic feature in HIV positive patients

DA Green, E Masliah, HV Vinters, P Beizai, DJ Moore… - Aids, 2005 - journals.lww.com
Background: We planned to analyze the prevalence and distribution of β-amyloid deposition
in the HIV+ brain in the HAART era. Our working hypothesis is that long term survival, aging …

Prevalence of cognitive disorders differs as a function of age in HIV virus infection

JT Becker, OL Lopez, MA Dew, HJ Aizenstein - Aids, 2004 - journals.lww.com
Objectives: Ten per cent of all new cases of AIDS in the United States are in persons older
than 50 years. This is particularly problematical in the case of the neuropsychiatric …

[HTML][HTML] Increased accumulation of intraneuronal amyloid β in HIV-infected patients

CL Achim, A Adame, W Dumaop, IP Everall… - Journal of Neuroimmune …, 2009 - Springer
In recent years, human immunodeficiency virus (HIV)-infected patients under highly active
anti-retroviral therapy (HAART) regimens have shown a markedly improved general clinical …

Neuroprotective and anti–human immunodeficiency virus activity of minocycline

MC Zink, J Uhrlaub, J DeWitt, T Voelker, B Bullock… - Jama, 2005 - jamanetwork.com
ContextThe prevalence of human immunodeficiency virus (HIV) central nervous system
(CNS) disease has not decreased despite highly active antiretroviral therapy. Current …

[HTML][HTML] Cerebrospinal fluid (CSF) neuronal biomarkers across the spectrum of HIV infection: hierarchy of injury and detection

J Peterson, M Gisslen, H Zetterberg, D Fuchs… - PloS one, 2014 - journals.plos.org
The character of central nervous system (CNS) HIV infection and its effects on neuronal
integrity vary with evolving systemic infection. Using a cross-sectional design and archived …

[HTML][HTML] Amyloid and tau cerebrospinal fluid biomarkers in HIV infection

M Gisslén, J Krut, U Andreasson, K Blennow, P Cinque… - BMC neurology, 2009 - Springer
Background Because of the emerging intersections of HIV infection and Alzheimer's
disease, we examined cerebrospinal fluid (CSF) biomarkers related of amyloid and tau …

Diffusion tensor imaging with quantitative fibre tracking in HIV infection and alcoholism comorbidity: synergistic white matter damage

A Pfefferbaum, MJ Rosenbloom, E Adalsteinsson… - Brain, 2007 - academic.oup.com
A substantial proportion of individuals infected with human immunodeficiency virus (HIV)
also abuse alcohol. Given that each condition can disrupt brain structural integrity, with a …

Involvement of quinolinic acid in AIDS dementia complex

GJ Guillemin, SJ Kerr, BJ Brew - Neurotoxicity research, 2005 - Springer
Human immunodeficiency virus (HIV) infection is often complicated by the development of
acquired immunodeficiency syndrome (AIDS) dementia complex (ADC). Quinolinic acid …