DNA G-quadruplex structures: more than simple roadblocks to transcription?
It has been> 20 years since the formation of G-quadruplex (G4) secondary structures in
gene promoters was first linked to the regulation of gene expression. Since then, the …
gene promoters was first linked to the regulation of gene expression. Since then, the …
G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders
Genomic DNA and cellular RNAs can form a variety of non-B secondary structures, including
G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held …
G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held …
Detection of genomic G-quadruplexes in living cells using a small artificial protein
Abstract G-quadruplex (G4) structures formed by guanine-rich nucleic acids are implicated
in essential physiological and pathological processes and serve as important drug targets …
in essential physiological and pathological processes and serve as important drug targets …
R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation
Abstract G-quadruplex (G4) is a noncanonical secondary structure of DNA or RNA which
can enhance or repress gene expression, yet the underlying molecular mechanism remains …
can enhance or repress gene expression, yet the underlying molecular mechanism remains …
Structure and function of multimeric G-quadruplexes
S Kolesnikova, EA Curtis - Molecules, 2019 - mdpi.com
G-quadruplexes are noncanonical nucleic acid structures formed from stacked guanine
tetrads. They are frequently used as building blocks and functional elements in fields such …
tetrads. They are frequently used as building blocks and functional elements in fields such …
G-quadruplexes in neurobiology and virology: functional roles and potential therapeutic approaches
A G-quadruplex (G4) is a four-stranded nucleic acid secondary structure maintained by
Hoogsteen hydrogen bonds established between four guanines. Experimental studies and …
Hoogsteen hydrogen bonds established between four guanines. Experimental studies and …
Single-molecule fluorescence studies on cotranscriptional G-quadruplex formation coupled with R-loop formation
G Lim, S Hohng - Nucleic acids research, 2020 - academic.oup.com
G-quadruplex (GQ) is formed at various regions of DNA, including telomeres of
chromosomes and regulatory regions of oncogenes. Since GQ is important in both gene …
chromosomes and regulatory regions of oncogenes. Since GQ is important in both gene …
Interaction between non-coding RNAs, mRNAs and G-quadruplexes
S Ghafouri-Fard, A Abak, A Baniahmad… - Cancer Cell …, 2022 - Springer
G-quadruplexes are secondary helical configurations established between guanine-rich
nucleic acids. The structure is seen in the promoter regions of numerous genes under …
nucleic acids. The structure is seen in the promoter regions of numerous genes under …
Selective targeting of guanine-vacancy-bearing G-quadruplexes by G-quartet complementation and stabilization with a guanine–peptide conjugate
Y He, K Zheng, C Wen, X Li, J Gong… - Journal of the …, 2020 - ACS Publications
Stabilization of G-quadruplexes (G4s) formed in guanine-rich (G-rich) nucleic acids by small-
molecule ligands has been extensively explored as a therapeutic approach for diseases …
molecule ligands has been extensively explored as a therapeutic approach for diseases …
Simple repeats as building blocks for genetic computers
A Herbert - Trends in Genetics, 2020 - cell.com
Processing of RNA involves heterogeneous nuclear ribonucleoproteins. The simple
sequence repeats (SSRs) they bind can also adopt alternative DNA structures, like Z DNA …
sequence repeats (SSRs) they bind can also adopt alternative DNA structures, like Z DNA …