Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and
illness in developed countries. ADRs show differential features depending upon genotype …

Background: Prevalence and impact of thiopurine S-methyltransferase (TPMT) and Nudix
hydrolase (NUDT15) minor allele frequencies in South Asian population is unclear …

The thiopurine drugs azathioprine and mercaptopurine are effective in the treatment of
disorders of immune regulation and acute lymphoblastic leukaemia. Although developed in …

Despite major advances in the management and high cure rates of childhood acute
lymphoblastic leukemia (ALL), patients still suffer from many drug-induced toxicities …

Pharmacogenomics (PGx) research and applications are of utmost relevance in Lebanon
considering its population genetic diversity. Moreover, as a country with regional leadership …

Cancer is the leading cause of death in American children older than 1 year of age. Major
developments in drugs such as thiopurines and optimization in clinical trial protocols for …

Thiopurines, including thioguanine (TG), 6-mercaptopurine (6-MP), and azathioprine (AZA),
are extensively used in clinical practice in children with acute lymphoblastic leukemia (ALL) …

Background Mercaptopurine-induced neutropenia can interrupt chemotherapy and expose
patients to infection during childhood acute lymphoblastic leukemia (ALL) treatment …

Background: 6-Mercaptopurine (6-MP) is the cornerstone of current antileukemia regimen
and contributes greatly to improve the survival of pediatric acute lymphoblastic leukemia …

6-Mercaptopurine (6-MP) is a cornerstone of the maintenance regimen for pediatric acute
lymphoblastic leukemia (ALL). Inosine triphosphate pyrophosphatase (ITPA) is considered a …