Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

Liquid–liquid Phase Separation (LLPS) of proteins and nucleic acids has emerged as a new
paradigm in the study of cellular activities. It drives the formation of liquid-like condensates …

Mutant p53 tends to form aggregates with amyloid properties, especially amyloid oligomers
inside the nucleus, which are believed to cause oncogenic gain-of-function (GoF). The …

Early in vivo studies demonstrated the involvement of a tumor-suppressing transcription
factor, p53, into cellular droplets such as Cajal and promyelocytic leukemia protein bodies …

Over 50% cancer bears TP53 mutation, the highly stabilized mutant p53 protein drives the
tumorigenesis and progression. Mutation of p53 not only cause loss-of-function and …

The global transcription factor, p53, is a master regulator of gene expression in cells.
Mutations in the TP53 gene promote unregulated cell growth through the inactivation of …

Despite being referred to as the guardian of the genome, when impacted by mutations, p53
can lose its protective functions and become a renegade. The malignant transformation of …

Liquid–liquid phase separation (LLPS) and phase transitions (PT) of proteins, which include
the formation of gel-and solid-like species, have been characterized as physical processes …

Liquid-liquid phase separation (LLPS) and phase transition (LLPT) of proteins and nucleic
acids have emerged as a new paradigm in cell biology. Here we will describe the recent …

Tumor-associated p53 mutations endow cells with malignant phenotypes, including
chemoresistance. Amyloid-like oligomers of mutant p53 transform this tumor suppressor into …