Converging evidence from genetic, pathological and experimental studies have increasingly
suggested an important role for autophagy impairment in Parkinson's Disease (PD). Genetic …

Lysosomal impairment is increasingly recognized as a central event in the pathophysiology
of PD. Genetic associations between lysosomal storage disorders, including Gaucher …

Background: Numerous studies have indicated that there is a possible relationship between
GBA variants and Parkinson's disease (PD), however, most of them focused on a few …

Deep brain stimulation is offered as symptomatic treatment in advanced Parkinson's
disease, depending on a clinical assessment of the individual patient's risk-benefit profile …

Several genetic studies have demonstrated an association between mutations in
glucocerebrosidase (GBA), originally implicated in Gaucher's disease, and an increased risk …

Parkinson's disease is the second most frequent neurodegenerative disease, representing a
significant medical and socio-economic problem. Modern medicine still has no answer to the …

Gaucher's disease (GD) is a genetic disorder in which glucocerebroside accumulates in
cells and specific organs. It is broadly classified into type I, type II and type III. Patients with …

This meta-analysis aims to investigate the association between mutations of
glucocerebrosidase (GBA) gene and susceptibility to Parkinson's disease (PD) in a …

In the last years, lysosomal storage diseases appear as a bridge of knowledge between rare
genetic inborn metabolic disorders and neurodegenerative diseases such as Parkinson's …

Gaucher's disease (GD) is the most prevalent lysosomal storage disorder. GD is caused by
homozygous mutations of the GBA1 gene, which codes for beta-glucocerebrosidase …