Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …

Volatile anaesthetics have historically been considered to act in a nonspecific manner on
the central nervous system,. More recent studies, however, have revealed that the receptors …

General anesthetics are widely used in clinical practice. On the molecular level, these
compounds have been shown to modulate the activity of various neuronal ion channels …

In this review first we evaluate evidence on the role of the neurobiological alterations
induced by chronic ethanol consumption in the development of ethanol tolerance …

Nicotinic acetylcholine receptors (AChRs) are a family of acetylcholine-gated cation
channels that form the predominant excitatory neurotransmitter receptors on muscles and …

The molecular mechanisms of general anaesthetics have remained largely obscure since
their introduction into clinical practice just over 150 years ago. This review describes the …

The 5-HT3 receptor is a member of the Cys-loop family of ligand-gated ion channels. These
receptors are located in both the peripheral and central nervous systems, where functional …

Serotonin type 3 (5-HT3) receptors are pentameric ion channels belonging to the
superfamily of Cys-loop receptors. Receptor activation either leads to fast excitatory …

The mechanisms of general anesthesia in the central nervous system are finally yielding to
molecular examination. As a result of research during the past several decades, a group of …