Despite significant advances in the field of cancer immunotherapy, the majority of patients
still do not benefit from treatment and must rely on traditional therapies. Dendritic cells have …

At the interface between the innate and adaptive immune system, dendritic cells (DCs) play
key roles in tumour immunity and hold a hitherto unrealized potential for cancer …

Abstract mRNA vaccines have become a versatile technology for the prevention of infectious
diseases and the treatment of cancers. In the vaccination process, mRNA formulation and …

Glioblastomas (GBM) are the most frequent and aggressive malignant primary brain tumor
and remains a therapeutic challenge: even after multimodal therapy, median survival of …

Vaccination against cancer by using dendritic cells has for more than a decade been based
on dendritic cells generated ex vivo from monocytes or CD34+ progenitors. Here, we report …

Mouse studies have shown that the immune system can reject tumours, and the
identification of tumour antigens that can be recognized by human T cells has facilitated the …

Dendritic cells (DCs) are critical for adaptive immunity and tolerance. Most DCs are
strategically positioned as immune sentinels poised to respond to invading pathogens in …

Purpose: We wanted to evaluate feasibility and safety of dendritic cell-based immunotherapy
in patients with metastatic renal cell carcinoma (RCC). Experimental Design: Patients with …

Substantial evidence shows that inflammation promotes oncogenesis and, occasionally,
participates in cancer rejection. This paradox can be accounted for by a dynamic switch from …

Dendritic cells are the professional antigen-presenting cells of the immune system. To
induce an effective immune response, these cells should not only express high levels of …