Adult hippocampal neurogenesis plays a critical role in memory and emotion processing,
and this process is dynamically regulated by neural circuit activity. However, it remains …

Traumatic brain injury (TBI) is a significant health care crisis that affects two million
individuals in the United Sates alone and over ten million worldwide each year. While …

This article provides an overview of the structure and function of substance P signalling
system and its involvement in the cardiovascular regulation. Substance P is an …

Introduction: Major depressive disorder (MDD) remains a major public health concern, and
one that continues to suffer an incompletely-met need for effective and acceptable …

The past two decades have witnessed an exponential increase in research into cancer. This
effort, however, has not been translated into better perspectives as regards the problem …

Type-2 diabetes is an adult onset condition that affects millions of people worldwide. The
ensuing hyperglycemia renders multiple organs to various complications and increases the …

The monoamine hypothesis of depression is increasingly called into question by newer
theories that revolve around changes in neuronal plasticity, primarily in the hippocampus, at …

Currently there are approximately 291,000 people suffering from a spinal cord injury (SCI) in
the United States. SCI is associated with traumatic changes in mobility and neuralgia, as …

Abstract Objective Substance P (SP) and norepinephrine (NE) containing sensory and
sympathetic nerve fibers innervate bone and fracture callus. They are involved in controlling …

We have investigated the effect of neurokinin 1 receptor (NK1R) agonists on HEK293 cells
transfected with the NK1R receptor. The NK1R receptor mediates dramatic shape changes …