The conditioned place preference (CPP) paradigm is a well-established model utilized to
study the role of context associations in reward-related behaviors, including both natural …

The hippocampus has been implicated in modulating anxiety. It interacts with a variety of
brain regions, both cortical and subcortical areas regulating emotion and stress responses …

Evidence suggests that the phytocannabinoids Δ-9-tetrahydrocannabinol (THC) and
cannabidiol (CBD) differentially regulate salience attribution and psychiatric risk. The ventral …

Background Stress is a major risk factor for depression, but not everyone responds to stress
in the same way. Identifying why certain individuals are more susceptible is essential for …

The endogenous opioid system is well known to relieve pain and underpin the rewarding
properties of most drugs of abuse. Among opioid receptors, the μ receptor mediates most of …

Social behaviors entail responses to social information and requires the perception and
integration of social cues through a complex cognition process that involves attention …

Abstract Cannabidiol (CBD) and Δ 9-tetrahydrocannabinol (THC) have been the most
investigated cannabinoids at the human and preclinical levels, although the neurobiological …

Humans and animals live in social relationships shaped by actions of approach and
avoidance. Both are crucial for normal physical and mental development, survival, and well …

Patients with neuropathic pain are usually accompanied by depression. Chemokine-
mediated neuroinflammation is involved in a variety of diseases, including …

Endocannabinoid system activity declines with age in the hippocampus, along with the
density of the cannabinoid receptor type-1 (CB1). This process might contribute to brain …