Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

The cancer stem cell (CSC) model has been established as a cellular mechanism that
contributes to phenotypic and functional heterogeneity in diverse cancer types. Recent …

The cancer stem cell (CSC) concept, which arose more than a decade ago, proposed that
tumor growth is sustained by a subpopulation of highly malignant cancerous cells. These …

Purpose Older patients with acute myeloid leukemia (AML) have a high relapse rate after
standard chemotherapy. We investigated whether measuring chemotherapy sensitivity by …

Prostate cancer is the most commonly diagnosed male malignancy. Despite compelling
epidemiology, there are no definitive aetiological clues linking development to frequency …

Stem cell differentiation pathways are most often studied at the population level, whereas
critical decisions are executed at the level of single cells. We have established a highly …

In recent years, major advances in single-cell measurement systems have included the
introduction of high-throughput versions of traditional flow cytometry that are now capable of …

While much research has examined the use of glucose and glutamine by tumor cells, many
cancers instead prefer to metabolize fats. Despite the pervasiveness of this phenotype …

Cancer is a heterogeneous disease manifest in many forms. Tumor histopathology can differ
significantly among patients and cellular heterogeneity within tumors is common. A primary …

Insight into the cancer cell populations that are responsible for relapsed disease is needed
to improve outcomes. Here we report a single-cell-based study of B cell precursor acute …