Tumour evolution in hepatocellular carcinoma

AJ Craig, J Von Felden, T Garcia-Lezana… - Nature reviews …, 2020 - nature.com
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, typically
develops on the background of chronic liver disease and is an aggressive disease with …

Background, current role, and potential applications of radiogenomics

K Pinker, F Shitano, E Sala, RK Do… - Journal of Magnetic …, 2018 - Wiley Online Library
With the genomic revolution in the early 1990s, medical research has been driven to study
the basis of human disease on a genomic level and to devise precise cancer therapies …

MRI radiomics features predict immuno-oncological characteristics of hepatocellular carcinoma

SJ Hectors, S Lewis, C Besa, MJ King, D Said… - European …, 2020 - Springer
Objective To assess the value of qualitative and quantitative MRI radiomics features for
noninvasive prediction of immuno-oncologic characteristics and outcomes of hepatocellular …

Intratumor heterogeneity: the hidden barrier to immunotherapy against MSI tumors from the perspective of IFN-γ signaling and tumor-infiltrating lymphocytes

W Wu, Y Liu, S Zeng, Y Han, H Shen - Journal of hematology & oncology, 2021 - Springer
In this era of precision medicine, with the help of biomarkers, immunotherapy has
significantly improved prognosis of many patients with malignant tumor. Deficient mismatch …

Combining molecular and imaging metrics in cancer: radiogenomics

R Lo Gullo, I Daimiel, EA Morris, K Pinker - Insights into imaging, 2020 - Springer
Background Radiogenomics is the extension of radiomics through the combination of
genetic and radiomic data. Because genetic testing remains expensive, invasive, and time …

Radiogenomics for predicting p53 status, PD-L1 expression, and prognosis with machine learning in pancreatic cancer

Y Iwatate, I Hoshino, H Yokota, F Ishige, M Itami… - British Journal of …, 2020 - nature.com
Background Radiogenomics is an emerging field that integrates “Radiomics” and
“Genomics”. In the current study, we aimed to predict the genetic information of pancreatic …

Radiomics in hepatocellular carcinoma: a quantitative review

T Wakabayashi, F Ouhmich, C Gonzalez-Cabrera… - Hepatology …, 2019 - Springer
Radiomics is an emerging field which extracts quantitative radiology data from medical
images and explores their correlation with clinical outcomes in a non-invasive manner. This …

[HTML][HTML] Severe hypoxia is a typical characteristic of human hepatocellular carcinoma: Scientific fact or fallacy?

T Cramer, P Vaupel - Journal of Hepatology, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is characterised by a robust resistance to therapy, resulting
in the very poor prognosis usually seen in patients with unresectable HCC. A thorough …

Diffusion-weighted MRI and diffusion kurtosis imaging to detect RAS mutation in colorectal liver metastasis

V Granata, R Fusco, C Risi, A Ottaiano, A Avallone… - Cancers, 2020 - mdpi.com
Simple Summary Imaging derived parameters can provide data on tumor phenotype as well
as cancer microenvironment. Radiomics has recently shown potential in realizing …

Radiomics of hepatocellular carcinoma

S Lewis, S Hectors, B Taouli - Abdominal Radiology, 2021 - Springer
The diagnosis of hepatocellular carcinoma relies largely on non-invasive imaging, and is
well suited for radiomics analysis. Radiomics is an emerging method for quantification of …