From discovery to function: the expanding roles of long noncoding RNAs in physiology and disease

M Sun, WL Kraus - Endocrine reviews, 2015 - academic.oup.com
Long noncoding RNAs (lncRNAs) are a relatively poorly understood class of RNAs with little
or no coding capacity transcribed from a set of incompletely annotated genes. They have …

Cell cycle regulation by long non-coding RNAs

M Kitagawa, K Kitagawa, Y Kotake, H Niida… - Cellular and molecular …, 2013 - Springer
The mammalian cell cycle is precisely controlled by cyclin-dependent kinases (CDKs) and
related pathways such as the RB and p53 pathways. Recent research on long non-coding …

[HTML][HTML] A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation

XY Zhao, S Li, GX Wang, Q Yu, JD Lin - Molecular cell, 2014 - cell.com
Brown and beige/brite fats generate heat via uncoupled respiration to defend against cold.
The total mass and activity of thermogenic adipose tissues are also tightly linked to systemic …

Long non-coding RNAs as regulators of the endocrine system

M Knoll, HF Lodish, L Sun - Nature Reviews Endocrinology, 2015 - nature.com
Long non-coding RNAs (lncRNAs) are a large and diverse group of RNAs that are often
lineage-specific and that regulate multiple biological functions. Many are nuclear and are …

Current methods of adipogenic differentiation of mesenchymal stem cells

MA Scott, VT Nguyen, B Levi… - Stem cells and …, 2011 - liebertpub.com
There has been a recent increase in our understanding in the isolation, culture, and
differentiation of mesenchymal stem cells (MSCs). Concomitantly, the availability of MSCs …

Regulation of key genes for milk fat synthesis in ruminants

T Mu, H Hu, Y Ma, X Feng, J Zhang, Y Gu - Frontiers in Nutrition, 2021 - frontiersin.org
Milk fat is the most important and energy-rich substance in milk and plays an important role
in the metabolism of nutrients during human growth and development. It is mainly used in …

Long non-coding RNAs in regulation of adipogenesis and adipose tissue function

T Squillaro, G Peluso, U Galderisi, G Di Bernardo - Elife, 2020 - elifesciences.org
Complex interaction between genetics, epigenetics, environment, and nutrition affect the
physiological activities of adipose tissues and their dysfunctions, which lead to several …

Non‐coding RNAs: biological functions and applications

B Santosh, A Varshney… - Cell biochemistry and …, 2015 - Wiley Online Library
Analyses of the international human genome sequencing results in 2004 converged to a
consensual number of~ 20 000 protein‐coding genes, spanning over< 2% of the total …

Long non-coding RNA ADNCR suppresses adipogenic differentiation by targeting miR-204

M Li, X Sun, H Cai, Y Sun, M Plath, C Li, X Lan… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Adipogenesis is a complex and precisely orchestrated process mediated by a network of
adipogenic regulatory factors. Several studies have highlighted the relevance of lncRNAs in …

Besides pathology: long non-coding RNA in cell and tissue homeostasis

A Salviano-Silva, SC Lobo-Alves, RC Almeida… - Non-coding RNA, 2018 - mdpi.com
A significant proportion of mammalian genomes corresponds to genes that transcribe long
non-coding RNAs (lncRNAs). Throughout the last decade, the number of studies concerning …