The burgeoning family of unconventional T cells
While most studies of T lymphocytes have focused on T cells reactive to complexes of
peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do …
peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do …
Inflammatory muscle diseases
MC Dalakas - New England Journal of Medicine, 2015 - Mass Medical Soc
Inflammatory Muscle Diseases | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
Six-of-the-best: unique contributions of γδ T cells to immunology
P Vantourout, A Hayday - Nature Reviews Immunology, 2013 - nature.com
Abstract γδ T cells are a unique and conserved population of lymphocytes that have been
the subject of a recent explosion of interest owing to their essential contributions to many …
the subject of a recent explosion of interest owing to their essential contributions to many …
γδ T Cells: First Line of Defense and Beyond
Y Chien, C Meyer, M Bonneville - Annual review of immunology, 2014 - annualreviews.org
γδ T cells, αβ T cells, and B cells are present together in all but the most primitive
vertebrates, suggesting that each population contributes to host immune competence …
vertebrates, suggesting that each population contributes to host immune competence …
Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions
M Deseke, I Prinz - Cellular & molecular immunology, 2020 - nature.com
T lymphocytes comprise cells expressing either an αβ or a γδ TCR. The riddle how αβ TCRs
are triggered by specific peptides presented in the context of MHC was elucidated some …
are triggered by specific peptides presented in the context of MHC was elucidated some …
Key features of gamma-delta T-cell subsets in human diseases and their immunotherapeutic implications
M Lawand, J Déchanet-Merville… - Frontiers in …, 2017 - frontiersin.org
The unique features of gamma-delta (γδ) T cells, related to their antigen recognition
capacity, their tissue tropism, and their cytotoxic function, make these cells ideal candidates …
capacity, their tissue tropism, and their cytotoxic function, make these cells ideal candidates …
The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness
D Melandri, I Zlatareva, RAG Chaleil, RJ Dart… - Nature …, 2018 - nature.com
T lymphocytes expressing γδ T cell antigen receptors (TCRs) comprise evolutionarily
conserved cells with paradoxical features. On the one hand, clonally expanded γδ T cells …
conserved cells with paradoxical features. On the one hand, clonally expanded γδ T cells …
The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research
R Hohlfeld, K Dornmair, E Meinl, H Wekerle - The Lancet Neurology, 2016 - thelancet.com
Interest in CD8+ T cells and B cells was initially inspired by observations in multiple
sclerosis rather than in animal models: CD8+ T cells predominate in multiple sclerosis …
sclerosis rather than in animal models: CD8+ T cells predominate in multiple sclerosis …
γδ TCR ligands: the quest to solve a 500-million-year-old mystery
BE Willcox, CR Willcox - Nature immunology, 2019 - nature.com
Abstract γδ T cells have been retained as a lineage over the majority of vertebrate evolution,
are able to respond to immune challenges in unique ways, and are of increasing therapeutic …
are able to respond to immune challenges in unique ways, and are of increasing therapeutic …
Risk factors and disease mechanisms in myositis
Autoimmune diseases develop as a result of chronic inflammation owing to interactions
between genes and the environment. However, the mechanisms by which autoimmune …
between genes and the environment. However, the mechanisms by which autoimmune …